Ese genes and proteins

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S070100, C435S252300, C435S320100, C435S325000, C536S023100, C536S023500, C536S024300, C536S024310

Reexamination Certificate

active

07118886

ABSTRACT:
The present invention describes the identification, isolation and characterization of novel mammalian proteins encoded by the Ese1 and Ese2 genes which are involved in endocytosis, vesicular trafficking and regulation of the actin cytoskeleton. Transcripts and products of these genes are useful for detecting abnormal cellular endocytosis processes as well as for developing assay systems to find and elucidate further binding partners of the proteins, to develop therapeutics to alter/restore protein function and for the isolation and manufacture of Ese proteins.

REFERENCES:
patent: 5717067 (1998-02-01), Fazioli et al.
patent: 6309820 (2001-10-01), Sparks et al.
patent: 2002/0034755 (2002-03-01), Sparks et al.
patent: WO 96 31625 (1996-10-01), None
MPSRCH search report, 2002, us-09-674-237a-3.rai, pp. 1-2.
Stanton, P et al, 1994, Br J Cancer, 70: 427-433.
Iehle, C et al, 1999, J Steroid Biochem Mol Biol, 68: 189-195.
Abbaszadegan, M R, et al, 1994, Cancer Res, 54: 4676-4679.
Gura (Science, 1997, 278:1041-1042).
Jain (Sci. Am., 1994, 271:58-65).
Curti (Crit. Rev. in Oncology/Hematology, 1993, 14:29-39).
Hartwell et al (Science, 1997, 278:1064-1068).
Bowie et al (Science, 1990, 257 : 1306-1310).
Burgess et al, (Journal of Cell Biology, 1990, 11: 2129-2138).
Lazar et al. Molecular and Cell Biology, 1988, 8: 1247-1252.
Tao. et al. The Journal of Immunology, 1989, 143(8): 2595-2601.
Gillies et al. Human Antibodies and Hybridomas, 1990, 1(1): 47-54.
Harris et al. J. of The Am Society of Nephrology 6:1125-33, 1995.
Ahn et al. Nature Genetics 3(4):283-91, 1993.
Cawthon et al. Genomics 9(3):446-60, 1991.
Miller (1995, FASEB J., vol. 9, pp. 190-199).
Deonarain (1998, Expert Opin. Ther. Pat., vol. 8, pp. 53-69).
Verma (Sep. 1997, Nature, vol. 389, pp. 239-242).
Crystal (1995, Science, vol. 270, p. 404-410).
Sparks, AB et al, 1996, Genbank Sequence Database (Accession U61166), or Nat. Biotechnol, 14(6): 741-744, 1996, and MPSRCH search report, 2003, us-09-674-273a-1.rge, pp. 28-30.
MPSRCH search report, 2003, us-09-674-273a-2.mpb, pp. 6-7.
Muller et al, 1992, Mol Cell Biol, 12: 5087-5093.
Sambrook et al, eds, 1989, Molecular Cloning, A laboratory manual, 2nd ed, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, p. 14.2-14.3.
H. Riezman, P. G. Woodman, G. van Meer, M. Marsh. Molecular mechanisms of Endocytosis. Cell 91: 731-738, 1997.
S. L. Schmid. Clathrin-coated vesicle formation and protein sorting: an integrated process. Annu. Rev. Biochem. 66: 511-548, 1997.
M. S. Robinson. Coats and budding vesicles. Trends Cell. Biol. 7: 99-102, 1997.
D. E. Warnock, S. L. Schmid. Dynamin GTPase, a force-generating molecular switch. BioEssays 18: 885-893, 1996.
R. Urrutia, J. R. Henley, T. Cook, M. A. McNiven. The dynamins: redundant or distinct functions for an expanding family of related GTPases? Proc. Natl. Acad. Sci. USA 94: 377-384, 1997.
P. Wigge, K. Kohler, Y. Vallis, C. A. Doyle, D. Owen, S. P. Hunt, H. T. McMahon. Amphiphysin Heterodimers: Potential Role in Clathrin-mediated Endocytosis. Molecular Biology of the Cell 8: 2003-2015, 1997.
A. L. Munn, B. J. Stevenson, M. J. Geli, H. Riezman. end5, end6 and end7:mutations that cause actin delocalization and block the internalization step of endocytosis inSaccharomyces cerevisiae. Molecular Biology of the Cell 6: 1721-1742, 1995.
O. Shupliakov, P. Low, D. Grabs, H. Gad, H. Chen, C. David, K. Takei, P. De Camilli, L. Brodin. Synaptic vesicle endocytosis impaired by disruption of dynamin-SH3 domain interactions. Science 276: 259-263, 1997.
P. Wigge, Y. Vallis, H. T. McMahon. Inhibition of receptor-mediated endocytosis by the amphiphysin SH3 domain. Current Biology 7: 554-560, 1997.
H. McLauchlan, J. Newell, N. Morrice, A. Osborne, M. West, E. Smythe. A novel role for Rab5-GDI in ligand sequestration into clathrin-coated pits. Current Biology 8: 34-45, 1997.
P. J. Robinson, J.-M. Sontag, J.-P. Liu, E. M. Fykse, C. Slaughter, H. McMahon, T. C. Sudhof. Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals. Nature 365: 163-166, 1993.
J.-P. Liu, A. T. R. Sim, P. J. Robinson. Calcineurin inhibition of Dynamin GTPase activity coupled to nerve terminal depolarization. Science 265: 970-973, 1994.
A. Wilde, F. M. Brodsky. In vivo phosphorylation of Adaptors regulates their interaction with Clathrin. The Journal of Cell Biology 135: 635-645, 1996.
R. Bauerfeind, K. Takei, P. De Camilli. Amphiphysin I is associated with coated endocytic intermediates and undergoes stimulation-dependent dephosphorylation in nerve terminals. J. Biol. Chem. 272: 30984-30992, 1997.
S. van Delft, R. Govers, G. J. Strous, A. J. Verkleij, P. M. P. van Bergen en Henegouwen. Epidermal growth factor induces ubiquitination of Eps15. Journal of Biological Chemistry 272: 14013-14016, 1997.
J.-M. Galan, R. Haguenauer-Tsapis. Ubiquitin Lys63 is involved in ubiquitination of a membrane plasma membrane protein. EMBO J 16: 5847-5854, 1997.
J. Terrel, S. Shih, R. Dunn, L. Hicke. A function for monoubiquitination in the internalization of a G protein-coupled receptor. Molecular Cell 1: 193-202, 1998.
R. Govers, P. van Kerkhof, A. L. Schwartz, G. J. Strous. Linkage of the ubiquitin-conjugating system and the endocytic pathway in ligand-induced internalization of the growth hormone receptor. EMBO J. 16: 4851-4858, 1997.
P. De Camilli, S. D. Emr, P. S. McPherson, P. Novick. Phosphoinositides as regulators in membrane traffic. Science 271: 1533-1539, 1996.
E. Kubler, H. Riezman. Actin and fimbrin are required for the internalization step of endocytosis in yeast. EMBO J. 12: 2855-2862, 1993.
H. Benedetti, S. Raths, F. Crausaz, H. Riezman. The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast. Mol. Biol. Cell. 5: 1023-1037, 1994.
M. I. Geli, H. Riezman. Role of Type I Myosin in receptor-mediated endocytosis in yeast. Science 272: 533-535, 1996.
H.-Y. Tang, M. Cai. The EH-domain-containing protein Pan1 is required for normal organization of the actin cytoskeleton inSaccaromyces cerevisiae. Mol. Cell. Biol. 16: 4897-1914, 1996.
V. Moreau, J.-M. Galan, G. Devilliers, R. Haguenauer-Tsapis, B. Winsor. The yeast Actin-related protein Arp2p is required for the internalization step of endocytosis. Molecular Biology of the Cell 8: 1361-1375, 1997.
B. Wendland, S. D. Emr. Pan1p, Yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis. Journal of Cell Biology 141: 71-84, 1998.
F. Fazioli, L. Minichiello, B. Matoskova, W. T. Wong, P. P. DiFiore. eps15, A novel tyrosine kinase substrate, exhibits transforming activity. Mol. Cell. Biol. 13: 5814-5828, 1993.
A. Benmerah, J. Gagnon, B. Begue, B. Megarbane, A. Dautry-Varsat, N. Cerf-Bensussan. The Tyrosine kinase substrate EPS15 is constitutively associated with the plasma membrane adaptor AP2. J. Cell Biol. 131: 1831-1838, 1995.
F. Tebar, T. Sorkina, A. Sorkin, M. Ericsson, T. Kirchausen. Eps15 Is a component of Clathrin-coated Pits and Vesicles and is located at the Rim of Coated Pits. Journal of Biological Chemistry 271: 28727-28730, 1996.
F. Tebar, S. Confalonieri, R. E. Carter, P. P. DiFiore, A. Sorkin. Eps15 is Constitutively Oligomerized due to Homolphilic interaction of its Coiled-coil domain. Journal of Biological Chemistry 272: 15413-15418, 1997.
R. Carbone, S. Fre, G. Iannolo, F. Belleudi, M. P., P. G. Pelicci, M. R. Torrisi, P. P. DiFiore. eps15 and eps15R are essential components of the endocytic pathway. Cancer Research 57: 5498-5504, 1997.
A. Benmerah, C. Lamaze, B. Begue, S. L. Schmid, A. Dautry-Varsat, N. Cerf-Bensussan. AP-2/Eps15 interaction is required for receptor-mediated endocytosis. Journal of Cell Biology 140: 1055-1062, 1998.
W. T. Wong, C. Schumacher, A. E. Salcini, A. Romano, P. Castagnino, P. G. Pelicci, P. P. Di Fiore. A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate EPS15 and conserved in evolution. Proc. Natl. Acad. Sci. USA 92: 9530-9534, 1995.
P. P. Di Fiore, P. G. Pelicci, A. Sorkin. EH: a novel protein-protein interactio

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