Esculentin A and esculentin B, a process for their preparation,

Details Esculentin A and esculentin B, a process for their preparation, Esculentin A and esculentin B, a process for their preparation,

1998-11-17

2000-08-22

Trinh, Ba K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549458, A61K 3134, C07D30777

Patent

active

061073350

ABSTRACT:
The compounds 18.beta., 19.beta.-diacetyloxy-18.alpha., 19.alpha.-epoxy-3, 13(16), 14-clerodatrien-2-one (Esculentin A) and 18.beta., 19.beta.-diacetyloxy-18.alpha., 19.alpha.-epoxy-3, 12, 14-clerodatrien-2.beta.-isovaleryloxy-6.beta., 7.alpha.-diol (Esculentin B) obtained from plants belonging to the Samydaceae family, particularly Casearia esculenta, a process for their preparation, and their use in the manufacture of medicaments. The compounds are particularly useful as anti-inflammatory and/or anti-cancer agents.

REFERENCES:
patent: 5468772 (1995-11-01), Xu et al.
Morita H. et al., "Structures and Cytotoxic Activity Relationship of Casearins, New Clerodane Diterpenes from Casearia sylvestris Sw.," Chem. Pharm. Bull., vol. 39, No. 3, pp. 693-697 (Mar. 1991).
Itokawa H. et al., "New Antitumor Principles, Casearins A-F, for Casearia sylvestris Sw. (Flacourtiaceae)," Chem. Pharm. Bull., vol. 38, No. 12, pp. 3384-3388 (Dec. 1990).
K. D. Choudhury et al., "Phytochemical and Hypoglycemic Investigation of Casearia Esculenta," Journal of Pharmaceutical Sciences, vol. 56, No. 11, pp. 1405-1409, Nov. 1967.
J. D. Hooker, "Sabiace.ae butted. to Cornace.ae butted.," Flora of British India, vol. II, pp. 590-598, L. Reeve & Co., London, 1879.

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