Escherichia coli vaccine

Details Escherichia coli vaccine Escherichia coli vaccine

1995-04-10

1998-05-12

Prouty, Rebecca E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4241851, 42419711, 4241901, 4242571, 4352521, 4352528, A61K 39108, C12N 120

Patent

active

057501157

ABSTRACT:
According to the present invention it has been found that a novel E. coli toxin or an immunogenic fragment thereof can be used in the preparation of vaccines for warm-blooded animals, and in particular for birds. Said toxin is found to be associated in flagellar structures attached to the bacteria, and these flagella or the free toxins can, after inactivation be used to immunize animals against E. coli infections.

REFERENCES:
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patent: 4886748 (1989-12-01), Asaka
H.T. Campbell et al., "Immunization with Flagella or Anti-Flagella Sera Protects Mice Against Salmonella-enteritidis", Absts. Ann. Meeting Am. Soc. Microbiol. 72: 101, Abst. M131, Apr. 1972.
M. Tanaka et al., "Production, Characterization, and Protective Effect of Monoclonal Antibodies to Clostridium chauvoei Flagella", Infect. Immun. 55(8) 1779-1783, Aug. 1987.
G. Resnick et al., "Improved Protection Against Cholera in Adult Rabbits with a Combined Flagellar-Toxoid Vaccine", Infect. Immun. 30(2) 375-380.
I.A. Holder et al., "Experimental Studies of the Pathogenesis of Infections Due to Pseudomonas aeruginosa : Immunization Using Divalent Flagella Preparations", J. Trauma, 26(2), 118-122, Feb. 1986.
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