Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Reexamination Certificate
2007-01-16
2007-01-16
Minnifield, Nita M. (Department: 1645)
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
C435S252100, C435S252800, C435S320100, C435S440000, C435S848000, C435S849000, C435S243000, C435S471000, C424S093100, C424S093200, C424S093400
Reexamination Certificate
active
09958081
ABSTRACT:
The invention relates to a strain suitable for producing a live, orally applicableEscherichia colivaccine for the prevention of post-weaning diarrhoea in pigs, and the procedure suitable for producing that strain. The essence of the strain is that the enterotoxin-free and originally wild-typeEscherichia colistrain simultaneously produces two adhesive fimbriae (F4 and F18), whereas the essence of the procedure is that the enterotoxin-producing ability if the wild, pathogenic, enterotoxigenicEscherichia colistrain originally capable of producing enterotoxins and F18 fimbriae is abolished by a genetic intervention while retaining the ability of the strain to produce F18 fimbria facilitating adhesion to the small intestinal wall of weaned piglets, and subsequently the strain thus modified is rendered capable of producing a further surface adhesion fimbria (F4).
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Fekete Zsolt
Nagy Bela
Olasz Ferenc
Abelman ,Frayne & Schwab
Minnifield Nita M.
MTA Allatorvos-Tudomanyi K.I.
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