Erythropoietin-mediated neurogenesis

Details Erythropoietin-mediated neurogenesis Erythropoietin-mediated neurogenesis

1998-10-20

2000-12-26

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435367, 435378, 435375, 514 2, 424 851, C12N 500

Patent

active

061657832

ABSTRACT:
Methods are described for the production of neurons or neuronal progenitor cells. Multipotent neural stem cells are proliferated in the presence of growth factors and erythropoietin which induces the generation of neuronal progenitor cells. The erythropoietin may be exogenously applied to the multipotent neural stem cells, or alternatively, the cells can be subjected to hypoxic insult which induces the cells to express erythropoietin.

REFERENCES:
patent: 5750376 (1998-05-01), Weiss et al.
Masuda et al. The Journal of Biological Chemistry. 269(30). 19488-19493, 1994.
Masuda et al. Brain Research. 746. 63-70, 1997.
Bauer. J. Perinat. Med. 23 7-12, 195.
Bauer, C., "Upregulation of erythropoietin by hypoxia in the brain of mammals", Wiener Klinische Wochenschrift 109: 535 (1997).
Digicaylioglu, M. et al., "Localization of specific erythropoietin binding sites in defined areas of the mouse brain", Proc. Nat'l. Acad. Sci. 92: 3717-3720 (1995).
Juul, S.E. and R.D. Christensen, "Erythropoietin (EPO) may promote neuronal suvival following hypoxia, by repressing apoptosis", Pediatric Research 41: 291A (1997).
Juul, S.E. et al., "Erythropoietin and erythropoiein receptor in the developing human central nervous system", Pediatric Research 43: 40-49 (1998).
Marti, H.H. et al., "Detection of erythropoietin in human liquor: intrinsic erythropoietin production in the brain", Kidney Int'l 51:416-418 (1997).
Sorokan, T. and S. Weiss, "Effects of hypoxia on neuronal production from embryonic murine CNS stem cells", Mol. Bio. of the Cell 7 (supp): 371A (1996).
Srolkan, T. and S. Weiss, "Erythropoietin mediates increased neurogenesis by embryonic CNS stem cells following a modes hypoxic insult", Society For Neurosciences Abstracts 23: 320 (1997).
Weiss, S. et al., "Is there a nerual stem cell in the mammalian forebrain?", Trends in Neurosciences 19: 387-393 (1996).
Bayer, Shirley A., "Neuron Production in the Hippocampus and Olfactory Bulb of the Adult Rat Brain: Addition or Replacement?", Annals N.Y. Acad. Sci., 457:163-173 (1985).
Freed, Curt R., et al., "Survival of Implanted Fetal Dopamine Cells and Neurologic Improvement 12 to 46 Months After Transplantation for Parkinson's Disease", N. Eng. J. Med., 327(22):1549-1555 (1992).
Kaplan, Michael S., "Neurogenesis in the 3-Month-Old Rat Visual Cortex", J. Comp. Neuro., 195:323-338 (1981).
Perlow, Mark J., et al., "Brain Grafts Reduce Motor Abnormalities Produced by Destruction of Nigrostriatal Dopamine System", Sci., 204:643-647 (May 1979).
Potten, C.S., et al., "Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the Crypt", Dev., 110:1001-1020 (1990).
Rakic, Pasko, "Limits of Neorogenesis in Primates", Sci., 227:1054-1056 (Mar. 1985).
Reynolds, Brent A., et al., "Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System", Sci., 255:1707-1710 (Mar. 1992).
Spencer, Dennis D., et al., "Unilateral Transplantation of Human Fetal Mesencephalic Tissue Into the Caudate Nucleus of Patients with Parkinson's Disease", N. Eng. J. Med., 327(22):1541-1548 (Nov. 1992).
Widner, Hakan, et al., "Bilateral Fetal Mesencephalic Grafting in Two Patients with Parkinsonism Induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)", N. Eng. J. Med., 327(22):1556-1563 (Nov. 1992).

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