Erythropoietin for treatment of multi-organ failure

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C530S399000

Reexamination Certificate

active

08067365

ABSTRACT:
The compositions and methods disclosed herein are for prevention or treatment of multi-organ failure with erythropoietin. The usefulness of the present invention is that erythropoietin may act to prevent the onset of MOF in a patient at risk of developing it. The present invention may further lessen the effect in one or more affected organs in a patient at risk of developing MOF or in one already diagnosed with it.

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Bahlmann et al. Low-dose therapy with the long-acting erythropoietin analogue darbepoietin alpha persistently activates endothelial Akt and attenuates progressive organ failure. Circulation vol. 110:1006-1012 (published on line Aug. 9, 2004).
Coleman et al. Science review: Recombinant human erythropoietin in critical illness: a role beyond anemia? Critical Care 8:337-341 (available online Jun. 16, 2004).
Parke et al. Multiple organ dysfunction syndrome. Inflammopharmacology, vol. 11, No. 1, pp. 87-95 (2003).
Gabriel et al. High-dose recombinant human erythropoietin stimulates reticulocyte production in patients with multiple organ dysfunction syndrome. Journal of Trauma 44(2):361-7 (Feb. 1998).

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