Erythropoietin (EPO) peptides

Details Erythropoietin (EPO) peptides Erythropoietin (EPO) peptides

1990-07-24

1992-04-21

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, C07K 700, A61K 3700

Patent

active

051069547

ABSTRACT:
Erythropoietin (EPO) peptides and the use thereof for preparing epitope-specific anti-EPO antibodies are described. Also described are corresponding anti-EPO antibodies which take the form of polyclonal antibodies (antisera) or of monoclonal antibodies. These antibodies are suitable for purifying EPO, EPO derivatives or EPO peptides. The epitope-specific anti-EPO antibodies according to the invention can also be used for the detection of EPO and, in particular, for the epitope-specific detection of EPO. Additionally described are anti-idiotype antibodies which imitate a receptor region of EPO. Finally, pharmaceuticals which contain the said EPO peptides, anti-EPO antibodies or anti-idiotype antibodies, and diagnostic aids for the detection of EPO or of anti-EPO antibodies, are described.

REFERENCES:
patent: 4558006 (1985-12-01), Egrie
Eschbach et al., New England Journal of Medicine, vol. 316, No. 2, 1987, pp. 73-78.
Lai et al., Journal Biol. Chem., vol. 26, No. 7, 1986, pp. 3116-3121.
Sytkowski et al., J. Biol. Chem., vol. 262, No. 3, 1987, pp. 1161-1165.
Graber et al., Ann. Rev. Med. 29:51-66 (1978).
Miyake et al., J. Biol. Chem., 252:5558-5564 (1977).
"Erythropoietin", The Lancet, (1987), pp. 781-782.
Axen et al., Nature, 214:1302-1304 (1967).

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