Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-02-03
2000-11-28
Fitzgerald, David L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 2351, 536 241, 530350, 530395, 514 2, 424 851, C12N 1516, C12N 1567, A61K 3818
Patent
active
061534072
ABSTRACT:
Provided are nucleic acids encoding erythropoietin (EPO) proteins and having modifications in the 5' and 3' noncoding sequences relative to the corresponding sequences in native EPO DNA. The invention also relates to the use of such nucleic acids to produce EPO proteins, which may have altered activity as compared to EPO proteins expressed from nucleic acids having native 5' and 3' sequences.
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Grodberg Jennifer
Sytkowski Arthur J.
Beth Israel Deaconess Medical Center
Fitzgerald David L.
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