Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1987-03-20
1989-05-30
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530350, 530380, 530399, 530395, 530829, 530830, 435 68, 4351723, 4352402, 514 8, 514 21, 514814, 935 13, 935 19, 935 70, 536 27, 536 28, 536 29, C07K 1300, C12N 1500, C12N 502, C12P 2102
Patent
active
048352608
ABSTRACT:
A new improved glycoprotein having erythropoietin-type activity is disclosed. The substrate is characterized by amino acid sequence substantially identical to the amino acid sequence of native human erythropoietin wherein the methionine-54 is replaced with leucine. DNA encoding for the EPO-substance and expression vectors incorporating the same are disclosed. Therapeutic compositions and methods for treatment of anemic conditions are described.
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Berstein David L.
Eisen Bruce M.
Genetics Institute Inc.
Kapinos Ellen J.
Kushan Jeff P.
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