Erythropoietin composition

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.

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530350, 530380, 530399, 530395, 530829, 530830, 435 68, 4351723, 4352402, 514 8, 514 21, 514814, 935 13, 935 19, 935 70, 536 27, 536 28, 536 29, C07K 1300, C12N 1500, C12N 502, C12P 2102

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active

048352608

ABSTRACT:
A new improved glycoprotein having erythropoietin-type activity is disclosed. The substrate is characterized by amino acid sequence substantially identical to the amino acid sequence of native human erythropoietin wherein the methionine-54 is replaced with leucine. DNA encoding for the EPO-substance and expression vectors incorporating the same are disclosed. Therapeutic compositions and methods for treatment of anemic conditions are described.

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