Erythropoietin and erythropoietin receptor expression in...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S397000

Reexamination Certificate

active

07432051

ABSTRACT:
The present invention relates to the elucidation of the role of erythropoietin and the erythropoietin receptor in the development and progression of certain solid tumors, including those found in breast, cervical, uterine, ovarian, prostate and brain cancer.

REFERENCES:
patent: 6103879 (2000-08-01), Chaovapong et al.
patent: 6310078 (2001-10-01), Connolly et al.
patent: WO 00/61637 (2000-10-01), None
Funakoshi et al., Gene expression of mutantn erythropoietin in hepatocellular carcinoma. Biochemical and Biophysical Research Communications, vol. 195, No. 2, pp. 717-722 (Sep. 15, 1993).
Westenfelder et al. Erythropoietin stimulates proliferation of human renal carcinoma cells. Kidney International, vol. 58 pp. 647-657 (Aug. 2000).
Horinouchi et al. Erythropoietin mRNA in hepatocellular carcinomas and kidney in male B6C3F1 mice with secondary polycythemia. Toxicologic Pathology, vol. 26, No. 5 pp. 682-686 (Sep.-Oct. 1998).
Benyo et al. (1999) Expression of the erythropoietin receptor by trophoblast cells in the human placenta, Biol. Reprod. 60:861-870.
Brown (1999) The hypoxic cell: a target for selective cancer therapy—eighteenth Bruce F. Cain Memorial Award lecture, Cancer Res. 59:5863-5870.
Bunn et al. (1996) Oxygen sensing and molecular adaptation to hypoxia, Physiol. Rev. 76:839-885.
Cerami (2001) Beyond erythropoiesis: novel applications for recombinant human erythropoietin, Semin. Hematol. 38:33-39.
Cheung et al. (2001) Molecular mechanisms of erythropoietin signaling, Nephron. 87:215-222.
Diagicaylioglu et al. (2001) Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades, Nature 412:641-647.
Graeber et al. (1996) Hypoxia-mediated selection of cells with diminshed apoptotic potential in solid tumours, Nature 379:88-91.
Jacobs et al. (1985) Isolation and characterization of genomic and cDNA clones of human erythropoietin, Nature 313:806-810.
Jones et al. (1990) Human erythropoietin receptor: cloning, expression, and biologic characterization, Blood 76:31-35.
Juul et al. (1999) Immunohistochemical localization of erythropoietin and its receptor in the developing human brain, Pediatr. Dev. Pathol. 2:148-158.
Juul et al. (1999) Why is erythropoietin present in human milk? Studies of erythropoietin receptors on enterocytes of human and rat neonates, Pediatr. Res. 46:263-268.
Kalra et al. (1993) The effect of hypoxia on acquired drug resistance and response epidermal growth factors in Chinese hamster lung fibroblasts and human breast-cancer cells in vitro, Int. J. Cancer 54:650-655.
Kling et al. (1998) Human milk as a potential enteral source of erythropoietin, Pediatr. Res. 43:216-221.
Marti et al. (1996) Erythropoietin gene expression in human, monkey and murine brain, Eur. J. Neurosci. 8:666-676.
Mitjavila et al. (1991) Autocrine stimulation by erythropoietin and autonomous growth of human erythroid leukemic cells in vitro, J. Clin. Invest. 88:789-797.
Sasaki et al. (2001) Pleiotropic functions and tissue-specific expression of erythropoietin, News Physiol. Sci. 16:110-113.
Schmatlz et al. (1998) Regulation of proliferation-survival decisions during tumor cell hypoxia, Mol. Cell Biol. 18:2845-2854.
Semenza (1999) Regulation of mammalian oxygen homeostasis by hypoxia-inducible factor 1, Annu. Rev. Cell Dev. Biol. 15:551-578.
Tachibana et al. (1991) Immunohistochemical study of erythropoietin in cerebellar hemangioblastomas associates with secodary polycythemia, Neurosurgery, 28:24-16.
Zagzag et al. (2000) Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasions, and progression, Cancer 88:2606-2618.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Erythropoietin and erythropoietin receptor expression in... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Erythropoietin and erythropoietin receptor expression in..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Erythropoietin and erythropoietin receptor expression in... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4000835

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.