Erythromycins and process for their preparation

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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Reexamination Certificate

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07807800

ABSTRACT:
14-membered macrolide compounds such as erythromycins are provided with functional groups at the 14- and/or 15-position by providing a 14-membered aglycone template and feeding it to a strain capable of hydroxylating it at the 14 and/or 15 position. The strain may be found by screening, selected from known strains (e.g.Streptomyces eurythermusDSM 40014) or produced by genetically engineering a strain to express a cytochrome P450 enzyme.

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