Erythromycin derivatives

Details Erythromycin derivatives Erythromycin derivatives

1990-04-18

1992-08-25

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 72, 435 76, 435882, A61K 3171, C07H 1708

Patent

active

051419262

ABSTRACT:
Novel 6-deoxyerythromycin derivatives are disclosed, as are methods for their preparation and use as antiinfective agents. The compounds of the invention include 6-deoxyerythromycins and 6-deoxy-15-norerythromycins which are represented by the structural formula ##STR1## in which R.sub.1 is selected from OH and H, and R.sub.2 and R.sub.3 are independently selected from H and CH.sub.3, as well as the pharmaceutically acceptable salts and esters of the above compounds. Additionally disclosed are genetically modified microorganisms which produce the compounds of the invention and means for the preparation of those microorganisms.

REFERENCES:
patent: 4331803 (1982-05-01), Watanabe et al.
patent: 4874748 (1989-10-01), Katz et al.

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