Erythromycin A 11,12-carbonates and method of use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 72, A61K 3171, C07H 1708

Patent

active

046862072

ABSTRACT:
Disclosed herein are erythromycin derivatives of the formula ##STR1## wherein R.sub.1 is lower alkyl, aryl, alkene, aryl halide, alkylamino, hydroxyalkyl and furanyl, and pharmaceutically acceptable salts thereof. These compounds have improved oral absorption, reduced effects on gastrointestinal motility, increased acid stability and longer serum half-lives.

REFERENCES:
patent: 3842068 (1974-10-01), Tadanier et al.
patent: 4476298 (1984-10-01), Morimoto et al.

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