Erythromycin A 11,12-carbonate and method of use

Details Erythromycin A 11,12-carbonate and method of use Erythromycin A 11,12-carbonate and method of use

1985-11-12

1987-07-21

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 72, A61K 3171, C07H 1708

Patent

active

046818723

ABSTRACT:
An erythromycin A derivative with high antimicrobial activity and improved pharmacokinetics is disclosed. 4"-Deoxyerythromycin A 11,12-carbonate and derivatives show superior in vitro and in vivo antimicrobial activity compared to erythromycin A, and when administered to animals has a serum half-life much prolonged over that of erythromycin A.

REFERENCES:
patent: 3417077 (1968-12-01), Murphy et al.
patent: 4382085 (1983-05-01), Sciavolino et al.
patent: 4382086 (1983-05-01), Sciavolino et al.

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