Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1980-12-01
1982-03-30
Michl, Paul R.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
523105, 524612, 524161, 524156, 524397, 424 19, C08K 509
Patent
active
043223230
ABSTRACT:
An erodible device is disclosed for delivering an agent to an environment of use. The device comprises (1) a structure sized and adapted for placement in an environment of use, the structure comprising a poly(orthoester) or a poly(orthocarbonate) having a repeating mer consisting of hydrocarbon radical and a symmetrical dioxycarbon unit of the general formula: ##STR1## wherein R.sub.1 is a multivalent hydrocarbon radical, R.sub.2 and R.sub.3 are hydrocarbon radicals with at least one of R.sub.2 or R.sub.3 bonded to the dioxycarbon through an oxygen covalent bond, (2) a beneficial agent, and (3) a surfactant erosion rate modifier. The devices are useful for delivering numerous agents to many environments. A composition also is disclosed comprising a poly(orthoester) or a poly(orthocarbonate), and a surfactant.
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ALZA Corporation
Mandell Edward L.
Michl Paul R.
Sabatine Paul L.
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