Erodible device comprising surfactant for modifying the rate of

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only

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523105, 524612, 524161, 524156, 524397, 424 19, C08K 509

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active

043223230

ABSTRACT:
An erodible device is disclosed for delivering an agent to an environment of use. The device comprises (1) a structure sized and adapted for placement in an environment of use, the structure comprising a poly(orthoester) or a poly(orthocarbonate) having a repeating mer consisting of hydrocarbon radical and a symmetrical dioxycarbon unit of the general formula: ##STR1## wherein R.sub.1 is a multivalent hydrocarbon radical, R.sub.2 and R.sub.3 are hydrocarbon radicals with at least one of R.sub.2 or R.sub.3 bonded to the dioxycarbon through an oxygen covalent bond, (2) a beneficial agent, and (3) a surfactant erosion rate modifier. The devices are useful for delivering numerous agents to many environments. A composition also is disclosed comprising a poly(orthoester) or a poly(orthocarbonate), and a surfactant.

REFERENCES:
patent: 3301824 (1967-01-01), Hostettler
patent: 3553117 (1971-01-01), Gutweiler
patent: 3652465 (1972-03-01), Takakura
patent: 3879348 (1975-04-01), Serini
patent: 4066747 (1978-01-01), Capozza
patent: 4079038 (1978-03-01), Choi
patent: 4119579 (1978-10-01), Capozza
patent: 4136252 (1979-01-01), Capozza
patent: 4140847 (1979-02-01), Orvik
patent: 4180646 (1979-12-01), Choi

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