Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-05-29
2010-02-23
Aulakh, Charanjit S (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S069000, C544S060000, C544S361000, C514S228200, C514S253030
Reexamination Certificate
active
07666877
ABSTRACT:
Disclosed are ergoline derivatives, Formula (I), wherein either each of R1and R2, independently, is H; optionally R10and/or R11-substituted-phenyl or -phenyl-C1-4alkyl; optionally R10and/or R11-substituted-heteroaryl or -heteroaryl-C1-4alkyl; optionally R10and/or R11-substituted heteroaryl N-oxide; optionally R10-substituted C1-C8alkyl; optionally R10-substituted C2-C8alkenyl, optionally R10-substituted C2-C8alkynyl; optionally R10-substituted C3-C8cycloalkyl, or optionally R10-substituted C4-C8cycloalkenyl; or R1and R2form together with the nitrogen atom to which they are attached an optionally R10-substituted 3-8 membered ring containing in addition to the nitrogen atom up to 2 heteroatoms selected independently from N, O and S; R3is H; OR1; CH2R1R2; (CH2)1-2NR1R2; CH2—CH2—OR1; CH2—CO—NR1R2; or CO—CH2R1R2; R4is F; Cl; Br; I; OR1; NR1R2or has one of the significances given for R1; and R5has one of the significances given for R1, in free form or in salt form for preventing or treating disorders or diseases mediated by interactions between chemokine receptors and their ligands.
REFERENCES:
patent: 00/42071 (2000-07-01), None
Nakahara, Yuji et al., Database CA [Online] Chemical Abstracts Service, Columbus, Ohio, “Lysergic acid diethylamide and related compounds. I. Synthesis of d-N6-demethyllysergic acid diethylamide”, XP002402827, Database accession No. 1972-34449 the abstract. the compound with the Registry-No. [35779-42-1] & Chemical & Pharmaceutical Bulletin 19 (11), pp. 2337-2341, Coden: CPBTAL; Issn: 0009-2363, (1971).
Baenteli Rolf
Glickman Fraser
Kovarik Jiri
Lewis Ian
Streiff Markus
Aulakh Charanjit S
Hoxie & Associates LLC
Novartis AG
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