Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2002-04-08
2004-03-23
Killos, Paul J. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C560S121000, C514S573000, C514S659000, C514S623000, C568S054000
Reexamination Certificate
active
06710081
ABSTRACT:
TECHNICAL FIELD
The present invention relates to a therapeutic agent for erectile dysfunction. More particularly, it relates to a therapeutic agent for erectile dysfunction containing as the active ingredient prostaglandin derivatives of general formula (I), nontoxic salts thereof or cyclodextrin clathrate compounds thereof, wherein each symbol is as defined below.
BACKGROUND ART
Male sexual dysfunction, in particular erectile dysfunction, is attributed to various causes such as aging, operation of prostate gland, injury of nerve cord, and diabetes. However, what is common in these causes is that a decrease of blood flow into the corpus cavernosum penis is the direct cause. As one of methods of treating it, administration of a vasodilator such as prostaglandin E
1
(hereinafter abbreviated as PGE
1
) has been considered effective (DICP—The animal of Pharmacotherapy, 5, 363 (1991)). However, PGE
1
has problems that it is attended with pain (angialgia) upon administration, that the drug itself is unstable and so forth.
On the other hand, it has been found that prostaglandin E
2
(hereinafter, abbreviated as PGE
2
) that has oxytocic effect also has utility for erectile dysfunction. This has made it unclear whether or not the erectile dysfunction improving action of PGE
1
is simply based on its vasodilating action without reservation (WO93/00894).
PGE
2
is known to be as a metabolite in the cascade of arachidonic acid and have various activities such as cytoprotection, oxytocic effect, algesic effect, promotion of vermicular movement of digestive tract, arousal effect, supression of gastric-acid secretion, hypotensive activity, and diuretic action.
Studies in recent years have revealed that PGE
2
receptors have subtypes that play different roles from each other. Currently known subtypes are roughly classified into four groups called EP
1
, EP
2
, EP
3
, and EP
4
, respectively (Negishi M. et al, J. Lipid Mediators Cell Signaling 12, 379-391 (1995)). Examination of separate roles of these receptors with compounds that bind to specific receptors and finding compounds not to bind any other subtype receptors has made it possible to obtain drugs having less side effects.
Recently, an application disclosing that a compound having an &ohgr;-chain modified with a hydroxyl group has an effect on erectile dysfunction equivalent to that of PGE
1
and is less irritating has been laid open to public inspection. It also describes that the compound disclosed therein is EP
2
-specific (cf., WO00/02164).
REFERENCES:
patent: 6462081 (2002-10-01), Maruyama et al.
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patent: WO 99/02164 (1999-01-01), None
patent: WO 00/003980 (2000-01-01), None
Narita Masami
Yoshida Kouzou
Killos Paul J.
Ono Pharmaceutical Co. Ltd.
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