Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1997-03-25
1999-10-19
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241421, 4241431, 4241521, 4241551, 435330, 435334, 435344, 435 71, 435 723, 5303877, 53038815, 5303881, 53038822, A61K 39395, G01N 33574, C12N 520, C07K 1600
Patent
active
059685115
ABSTRACT:
Antibodies are disclosed which bind to ErbB3 protein and further possess any one or more of the following properties: an ability to reduce heregulin-induced formation of an ErbB2-ErbB3 protein complex in a cell which expresses ErbB2 and ErbB3; the ability to increase the binding affinity of heregulin for ErbB3 protein; and the characteristic of reducing heregulin-induced ErbB2 activation in a cell which expresses ErbB2 and ErbB3.
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Akita Robert
Sliwkowski Mark
Bansal Geetha P.
Genentech Inc.
Hutzell Paula K.
Lee Wendy M.
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