erbB-2 gene segments, probes, recombinant DNA and kits for detec

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 691, 4351723, 4353201, 435810, 436501, 436 63, 536 231, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 935 77, 935 78, C12Q 168

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059855533

ABSTRACT:
The isolation, cloning and characterization of a human gene related to but distinct from the EGF receptor gene has been described. Nucleotide sequence of the gene and amino acid sequence of the polypeptide encoded by the gene have been determined. The use of the nucleic acid probes and antibodies having specific binding affinity with said polypeptide for diagnostic and therapeutic purposes has also been described.

REFERENCES:
patent: 4753894 (1988-06-01), Frankel et al.
patent: 4968603 (1990-11-01), Slamon et al.
New England Biolabs Catalog (Published By New England Biolabs, Beverly, MA, USA 1986/87) pp. 60-62.
A.A. King, et al. Cell Membr. Cancer Proc. Intl. Workshop, 2nd., pp. 411-416 (1985).
BB. Semba, et al. "A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma" PNAS, USA 82: 6497-6501 (Oct., 1985).
CC. Schechter, et al. "The neu oncogene: an erb-B-related gene encoding a 185,000-M.sub.r tumour antigen" Nature 312: 513-516 (Dec. 6, 1984).
DD. King, et al. "Amplification of a Novel erbB-Related Gene in a Human Mammary Carcinoma" Science 229: 974-6 (Sep. 6, 1985).
EE. Schecter, et al. Science 229: 976-8 (Sep. 6, 1985).
FF. King, et al. "Oncogenes as growth factors . . . erbB-related gene" in Chem. Abstracts 104(17): 142890e (Apr. 28, 1986) (corresponds to AA).
Palk, S. et al. "Pathologic Findings From the National Surgical Adjuvant Breast and Bowel Project; Prognostic Significence of erbB-2 Protein Overexpression in Primary Breast Cancer" J. of Clinical Oncology (1990) 5:103-112.
King, C.B. et al. "Hetergeneous Expression of erbB-2 Messenger RNA in Human Breast Cancer" Cancer Research(1989) 49:4185-4191.
Park, J-S, et al, "Application, Overexpression, and Rearrangement of erbB-2 Protooncogene in Primary Human Stomach Carcinomes" Cancer Research (1989) 49:6605-6609.
King, C.R. et al. "Implications of erbB-2 overexpression for basic science and clinical medicine" Examiners in Cancer Biology (1990) 1:329-337.
Berger, M.S. et al. "Correlation of c-erbB-2 Gene Amplification and Protein Expression in Human Breast Carcinoma with Model Status and Nuclear Grading" Cancer Research (1988) 48:1238-1243.
A. Ullrich et al., "Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene A431 epidermoid carcinoma cells," Nature (1984) vol. 309, pp. 418-425.
King et al., Amplification of a Novel v-erbB-Related Gene in a Human Mammary Carcinoma, Science, (1985) 229:974-976.
Kraus et al., Overexpression of the EGF Receptor-Related Proto-Oncogene erbB-2 in Human Mammary Tumor Cell Lines . . . The EMBO Journal, (1987) 6:605-610.
Di Foire et al., erbB-2 Is A Potent Oncogene When Overexpressed in NIH/3T3 Cells, Science., , (1987) 237:178-182.
Lacroix et al., Overexpression of erbB-2 or EGF Receptor Proteins Present In Early Stage Mammary . . . Oncogene, (1989) 4:145-151.
Slamon et al., Human Breast Cancer: Correlation of Relapse and Survival with . . . , Science, (1987), 235:177-182.
Downward, et al. Nature 307:521-527, 1984.
Ullrich, et al., Nature 309:418-425, 1984.
Doolittle, et al. Science 221:275-277, 1983.
Lin, et al. Science 224:843, 1984.
Rigby, et al., J. Mol. Biol. 113:237, 1977.
Wahl, et al. Proc. Natl. Acad. Sci USA 76:3686, 1979.
de Klein, et al., Nature 300:765, 1982.
Collins, et al. Proc. Natl. Acad. Sci. USA 80:4813, 1983.
Liberman, et al., Nature 313:144, 1985.
Kasuga et al. Nature 298:667-669, 1982.
Rubin, et al. Nature 305:438-440, 1983.
Yamamoto, et al. Cell 35:71-78, 1983.
Land et al., Science 222:771-778, 1983.
Cohen, et al., J. Biol. Chem 255:4834-4842, 1980.
Nishimura, et al. Proc. Natl. Acad. Sci. USA 79:4303-4307, 1982.
Sedlak (1994) Genetic Engineering News of May 15, 1994, pp. 8-9.
Brison (1993) Biochemica et Biophysica Acta, vol. 1155, pp. 25-41.
Sembo et al. (1985) Proc. Natl. Acad. Sci. (USA), vol. 82, pp. 6497-6501.
Yamamoto et al. (1986) Nature, vol. 319, pp. 230-234.
Ring et al. "Identity of BCA200 and c-erbB-2 Indicated by Reactivity of Monoclonal Antibodies with Recombinant c-erbB-2" Mol. Immunol. 28(8):915-917, 1991.
Ring et al. "Distribution and Physical Properties of BCA200, a M, 200,000 Glycoprotein Selectively Associated with Human Breast Cancer" Cancer Res. 49:3070-3080, Jun. 1, 1989.
Coussens et al. "Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene" Science 230:1132-1139, Dec. 6, 1985.
Pirker et al. "Characterization of Immunotoxins Active Against Ovarian Cancer Cell Lines" J. Clin. Invest. 76:1261-1267, Sep. 1985.
Frankel et al. "Tissue Distribution of Breast Cancer-Associated Antigens Defined by Monoclonal Antibodies" J. Biol. Resp. Modifiers 4:273-286, 1985.
Bjorn et al. "Evaluation of Monoclonal Antibodies for the Development of Breast Cancer Immunotoxins" Cancer Res. 45:1214-1221, Mar. 1985.

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