Eradication of pathogenic biological contaminants using non-azo

Details Eradication of pathogenic biological contaminants using non-azo Eradication of pathogenic biological contaminants using non-azo

1993-08-09

1995-05-30

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

424 117, 424 133, 424 149, 424 165, 424 181, 514284, 514885, 546 76, 546 77, 546 97, 546 22, 546 23, 546 88, 546 98, 546100, 546 13, 546 14, 540467, A61K 31435, A61K 31535, A61K 3154, A61K 3900

Patent

active

054201365

ABSTRACT:
A class of predominantly hydrophobic non-azo N-substituted 1,8-naphthalimide compounds, each bearing, at its 3-position, a nucleofuge and, at its 4-position, a heteroatomic electron-releasing group. The heteroatomic electron-releasing group is being characterized as having a heteroatom directly linked to the 4-position of the ring, and having at least one hydrogen directly attached to the heteroatom. Upon activation by an activating agent in an environment independent of the presence or absence of oxygen, these compounds generate activated species. The activated species initiate chemical changes in lipid bilayer membranes of viruses and other target cells. These changes can eradicate viruses and other target cells. The activated species can also cause structural changes in lipid and any associated proteins and polypeptides at a level beneath the surface of the membrane, leading to polymerization and crosslinking.

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