Liquid purification or separation – Processes – Chromatography
Reexamination Certificate
2003-07-24
2008-07-22
Therkorn, Ernest G (Department: 1797)
Liquid purification or separation
Processes
Chromatography
C210S659000, C210S101000, C210S143000, C210S198200
Reexamination Certificate
active
07402250
ABSTRACT:
It is an object of the present invention to improve the performance of gradient liquid transfer in nano/micro liquid chromatographs when solvents are mixed.In a gradient liquid transfer device and method for a nano/micro liquid chromatograph, an opening and closing unit (160) capable of opening and closing a solvent passage (150) for transferring a secondary solvent is provided in the vicinity of a solvent mixing section (152) in a liquid transfer system (130); a passage from a metering pump (146) of a liquid transfer section (142) to the opening and closing unit (160) is filled with the secondary solvent in advance; and an appropriate pressure is applied to the secondary solvent. Therefore, the entry of a primary solvent into the solvent passage for transferring the secondary solvent is suppressed. In another gradient liquid transfer device and method for a nano/micro liquid chromatograph, a liquid having a low compression rate is filled, in advance, in a part of a solvent passage subsequent to a metering pump of a liquid transfer section, and only the required amount of a secondary solvent is filled subsequent to the liquid. Therefore, the entry of the primary solvent into a solvent passage for transferring the secondary solvent is suppressed, and liquid-transfer performance is improved.
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Kudo Ken-ichi
Yamauchi Yoshio
KYA Technologies Corporation
Rankin , Hill & Clark LLP
Therkorn Ernest G
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