Equine P-selectin glycoprotein ligand-1 and uses thereof

Details Equine P-selectin glycoprotein ligand-1 and uses thereof Equine P-selectin glycoprotein ligand-1 and uses thereof

2004-11-12

2008-12-02

Landsman, Robert (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C514S002600, C514S012200

Reexamination Certificate

active

07459523

ABSTRACT:
A novel equine P-selectin glycoprotein ligand-1 (ePSGL-1) is disclosed having the amino acid sequence set forth in SEQ ID NO:2. DNA sequences encoding the ePSGL-1 are also disclosed, along with vectors, host cells, and methods of making the ePSGL-1. The invention further provides methods for preventing or reducing acute inflammatory response in an equine subject by administering ePSGL-1 and fragments thereof (e.g., an ePSGL-1-Ig fusion protein). The invention also provides methods for identifying compounds capable of reducing or preventing damage to tissue or organs caused by acute inflammatory response in an equine subject.

REFERENCES:
patent: 6124267 (2000-09-01), McEver et al.
patent: 6277975 (2001-08-01), Larsen et al.
patent: 6852497 (2005-02-01), Lorenz et al.
patent: 2002/0028205 (2002-03-01), Holgersson et al.
patent: 2002/0037840 (2002-03-01), Lorenz et al.
patent: 2002/0058034 (2002-05-01), Manjunath et al.
patent: 2003/0049252 (2003-03-01), Lin et al.
patent: 2004/0116333 (2004-06-01), Lin et al.
patent: 2005/0152904 (2005-07-01), Lorenz et al.
patent: WO98/08949 (1998-03-01), None
patent: WO 9808949 (1998-03-01), None
patent: WO99/43834 (1999-09-01), None
Afshar-Kharghan V et al. (2001); Blood 97, 3306-3307.
Bundgaard J R et al. (1997); J Biol Chem 272, 21700-21705.
Cummings R D (1999); Brazilian Journal of Medical and Biological Research 32, 519-528.
Epperson T K et al. (2000); J Biol Chem 275, 7839-7853.
Hicks A E R et al. (2002); FASEB J 15, 1461-1462.
Lalko C C et al. (2003); Vet Immunology and Immunopathy 91, 119-134.
Leppänen A (2000); J Biol Chem 275, 39569-39578.
McEver R P et al. (1997); J Clin Invest 100, 485-492.
Moore K L (1998); Leukemia and Lymphoma 29, 1-15.
Rodgers S D et al. (2001); Biophys J 81, 2001-2009.
Snapp K R et al. (1998); J Cell Biol 142, 263-270.
Somers W S et al. (2000); Cell 103, 467-479.
Wilkins P P et al. (1996); J Biol Chem 271, 18732-18742.
Xia L et al. (2003); Blood 101, 552-559.
Veldman G et al. (1995); J Biol Chem 270, 16470-16475.
EMBL Sequence Version Archive Feb. 18, 2004; Accession No. AY298766.
Xu, J., et al. Mammalian Genome: Official Journal of the International Mammalian Genome Society 16:66-71 (Jan. 2005).
Darien, B.J. “Proceedings of a Workshop on Equine Immunology 2001” Havemeyar Foundation Monograph Series No. 4, pp. 91-93 (2001).

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