Equimolar multiple oligomer mixtures, especially oligopeptide mi

Details Equimolar multiple oligomer mixtures, especially oligopeptide mi Equimolar multiple oligomer mixtures, especially oligopeptide mi

1994-06-03

1996-04-02

Warden, Jill

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

530328, 530327, 530326, 530325, 530324, A61K 3804, C07K 500, C07K 700, C07K 1600

Patent

active

055041906

ABSTRACT:
A process for the synthesis of a complex mixture pool of solid support-coupled monomeric repeating unit compounds such as amino acid derivatives is disclosed in which the mixture pool contains an equimolar representation of reacted monomeric repeating unit compounds coupled. Also disclosed is a process for the stepwise synthesis of a complex mixture of coupled or free, unsupported oligomers such as oligopeptides. A set of self-solubilizing, unsupported mixed oligopeptides having one or more predetermined amino acid residues at one or more of the same, predetermined positions in the oligopeptide chain in which the set contains equimolar amounts of a plurality of different amino acid residues, preferably at least six different residues, at one or more of the same predetermined positions of the oligopeptide chain is also disclosed, as are methods of making and using the same.

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