Equilin hapten and assay method

Details Equilin hapten and assay method Equilin hapten and assay method

1980-09-29

1983-04-12

Nucker, Christine M.

Chemistry: analytical and immunological testing

Involving producing or treating antigen or hapten

260112B, 2603974, 2603975, 260112R, 436804, 436817, 436822, 436823, G01N 3354, G01N 3356, C07G 700, C07J 1300

Patent

active

043797792

ABSTRACT:
A hapten is obtained by replacing the 3-hydroxy group of equilin with HO--CO--A--O-- wherein A is an alkylene of one to six carbon atoms. The hapten is conjugated with an immunological carrier to provide an immunogen, which in turn produces a specific antiserum to equilin. The antiserum is used in a radioimmunoassay for equilin.

REFERENCES:
patent: 4128629 (1978-12-01), Eldred et al.
patent: 4293536 (1981-10-01), Jensen et al.
La Bella et al., Chem. Abstracts, vol. 90, 1979, Abstract #66958h.
Rance et al., J. Steroid Biochem., vol. 9, 1978, pp. 1065-1069.
Rao et al., Steroids, vol. 29, 1978, pp. 461-469.
Whittaker et al., Lancet, vol. 1, 1980, pp. 14-16.
Morgan et al., J. Steroid Biochem., vol. 13, 1980, pp. 551-555.
Johnson et al., J. Pharm. Sci., vol. 67, 1978, pp. 1218-1224.
Rao et al., Ligand Quarterly, vol. 3, No. 1, 1980, p. 53.

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