Epstein-barr virus transformed cell lines superinfected with a s

Details Epstein-barr virus transformed cell lines superinfected with a s Epstein-barr virus transformed cell lines superinfected with a s

1988-04-29

1993-01-12

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 5, 435 72, 435 721, 435 724, 4352402, 43524026, 435948, 435974, C12Q 100, C12Q 170, G01N 3353, C12N 500, C12N 100

Patent

active

051789990

ABSTRACT:
A cell line transformed by EBV and infected with a virus, e.g., HIV, which cell line does not release extracellular virus, but which forms syncytia when 1) these cells are co-cultivated with lymphocytes permissive for HIV infection and 2) antibodies to HIV are not present (syncytia formation is specifically inhibited by antibodies by HIV).
Syncytial formation induced by cell lines not producing detectable HIV provides a unique and less hazardous test for the detection of non-productive HIV infection as well as for the determination of antibody response to HIV vaccines.

REFERENCES:
Person, S. et al. 1982, Virology 117 293-306.
J. M. Keller. 1976. Virology 72 402-409.
White, J. et al. 1983. Quant. Rev. Biophys. 16 151-195.
Capone, Jr. et al. 1982. J. Biol. Chem. 257 16-19.
McIntosh, K. 1985. In: Virology. ed B. N. Fields, pp. 309-322.
K. Dahl, K. Martin and G. Miller, "Differences Among Human Immunodeficiency Virus Strains in Their Capacities to Induce Cytolysis or Persistent Infection of a Lymphoblastoid Cell Lines Immortalized by Epstein-Barr Virus", Journal of Virology, vol. 61, No. 4, 1602-1608, May 1987.

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