Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-11-30
2000-03-28
Houtteman, Scott W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 2432, 536 2372, C07H 2104
Patent
active
060433515
ABSTRACT:
The present invention relates, in general, to Epstein Barr virus induced (EBI) genes. In particular, the present invention relates to DNA segments coding for EBI 1, EBI 2, or EBI 3 polypeptides; EBI 1, EBI 2, or EBI 3 polypeptides; recombinant DNA molecules; cells containing the recombinant DNA molecules; antisense EBI 1, EBI 2, or EBI 3 constructs; antibodies having binding affinity to an EBI 1, EBI 2, or EBI 3 polypeptide; hybridomas containing the antibodies; nucleic acid probes for the detection of the presence of Epstein Barr Virus; a method of detecting Epstein Barr virus in a sample; and kits containing nucleic acid probes or antibodies.
REFERENCES:
Alfieri et al., "Early Events in Epstein-Barr Virus Infection of Human B Lymphocytes", Virology 181:595-608 (1991).
Bayliss, G.J. and Wolf, H., "The Regulated expression of Epstein-Barr Virus. III. Proteins Specified by EBV During the Lytic Cycle", J. gen. Virol. 56:105-118 (1981).
Bayliss et al., "An Immunoprecipitation Blocking Assay for the Analysis of EBV Induced Antigens", J. of Virol. Methods 7:229-239 (1983).
Birkenbach et al., "Epstein-Barr Virus Latent Infection Membrane Protein Increases Vimentin Expression in Human B-Cell Lines", J. of Virology 63(9):4079-4084 (1989).
Calender et al., "Epstein-Barr Virus (EBV) Induces Expression of B-Cell Activation Markers on in Vitro Infection of EBV-Negative B-Lymphona Cells", Proc. Natl. Acad. Sciences USA 84:8060-8064 (1987).
Favrot et al., "EBV-Negative and -Positive Burkitt Cell Lines Variably Express Receptors for B-Cell Activation and Differentiation", Intl. J. of Cancer 38:901-906 (1986).
Ehlin-Henriksson et al., "Expression of B-Cell-Specific Markers in Different Burkitt Lymphoma Subgroups", Intl. J. of Cancer 39:211-218 (1987).
Gregory et al., "Different Epstein-Barr Virus-B Cell Interactions in Phenotypically Distinct Clones of a Burkitt's Lymphona Cell Line", J. of General Virology 71:1481-1495 (1990).
Henderson et al., "Induction of bcl-2 Expression by Epstein-Barr Virus Latent Membrane Protein 1 Protects Infected B cells from Programmed Cell Death", Cell 65:1107-1115 (1991).
Hummel, M. and Kieff, E., "Mapping of Polypeptides Encoded by the Epstein-Barr Virus Genome in Productive Infection", Proc. Natl. Acad. Sci. USA 79:5698-5702 (Sep. 1982).
Knutson, J.C., "The Level of c-fgr RNA is Increased by EBNA-2, an Epstein-Barr Virus Gene Required for B-Cell", J. of Virology 64(6):2530-2536 (1990).
Qualtiere, L.F. and Pearson, G.R., "Epstein-Barr Virus-Induced Membrane Antigens: Immunochemical Characterization of Triton X-100 Solubilized Viral Membrane Antigens from EBV-Superinfected Raji cells", Int. J. Cancer 23:808-817 (1979).
Rowe et al., "Epstein-Barr Virus Status and Tumour Cell Phenotype in Sporadic Burkitt's Lymphoma", Intl. J. of Cancer 37:367-373 (1986).
Rowe et al., "Differences in B Cell Growth Phenotype Reflect Novel Patterns of Epstein-Barr Virus Latent Gene Expression in Burkitt's Lymphoma Cells", EMBO Journal 6(9):2743-2751 (1987).
Spira et al., "Cell-Surface Immunoglobulin and Insulin Receptor Expression in an EBV-Negative Lymphoma Cell Line and Its EBV-Converted Sublines", J. of Immunology 126(1):122-126 (1981).
Thorley-Lawson et al., "BLAST-2 [EBVCS], an Early Cell Surface Marker of Human B Cell Activation, is Superinduced by Epstein Barr Virus", J. of Immunology 134(5):3007-3012 (1985).
Wang et al., "Epstein-Barr Virus Latent Membrane Protein (LMP1) and Nuclear Proteins 2 and 3C are Effectors of Phenotypic Changes in B Lymphocytes: EBNA-2 and LMP1 Cooperatively Induce CD23", J. of Virology 64(5):2309-2318 (1990).
Wang et al., "Epstein-Barr Virus Nuclear Antigen 2 Specifically Induces Expression of the B-Cell Activation Antigen CD23", Proc. Natl. Acad. Sciences USA 84:3452-3456 (1987).
Wang et al., "Epstein-Barr Virus Nuclear Antigen 2 Transactivates Latent Membrane Protein LMP1", J. of Virology 64(7):3407-3416 (1990).
GenBank Acc. No. T02587, May 26, 1992.
Stratagene Catalog, 1988 p. 39.
Birkenbach Mark
Kieff Elliot
Brigham and Women's Hospital
Houtteman Scott W.
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