Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1995-05-25
2000-06-06
Schwadron, Ronald B.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530350, 530384, 5303879, 53038822, 53038824, 53038825, 5303887, 53038873, 53038875, 5303892, 5303893, 5303896, 530395, 530300, C07K 14705, C07K 14745, C07K 1628, C07K 1636
Patent
active
06072028&
ABSTRACT:
A new class of cellular receptors extensively homologous but not identical to coagulation factors V and VIII is identified. The DNA and amino acid residue sequences of the receptor are also described. The invention also discloses methods, sequences and vectors useful in the purification and synthesis of cellular receptors of the present invention, which receptors are identified herein as Effector Cell Protease Receptor-1 (EPR-1). Antibody compositions capable of immunoreacting with the receptor or with polypeptides containing the identified amino acid residue sequences and related therapeutic and diagnostic protocols are also described, as are polypeptides, compositions and methods relating to the inhibition of T lymphocyte proliferation using the antibodies disclosed herein. The present invention also discloses polypeptides, antibodies and compositions capable of stimulating or co-stimulating lymphocyte proliferation.
REFERENCES:
ATCC Cell Lines and Hybridomas, 8.sup.th Edition, 1944, American Type Culture Collection, pp. 339, xv and xvi.
Rudinger, Chapter 1, from: "Peptide Hormones", Ed. J.A. Parsons, Univ. Park Press, 1976, pp. 1-7.
Miles, L. A., et al., Fibrinolysis 2: 61 (1988).
Morrissey, et al., Cell 50: 129 (1987).
Nesheim, M. E., et al., J. Biol. Chem. 254: 10952 (1979).
Chen, L. B., et al., PNAS USA 72: 131 (1975).
Glenn, K. C., et al., Nature 278: 711 (1979).
Baker, J. B., et al., Nature 278: 743 (1979).
Unkeless, J. C., et al., J. Exp. Med. 137: 85 (1973).
Sullivan, L. M., et al., Cell 45: 905 (1986).
Fenner, F. et al. in The Orthopoxviruses, Acad. Press, San Diego (1989).
Boyle, M.D.P., et al., J. Immunol. 139: 169 (1987).
Bar-Shavit, R., et al., Science 220: 728 (1983).
Redelman, D., et al., J. Immunol. 124: 870 (1980).
Chang, T. W., et al., J. Immunol. 124: 1028 (1980).
Suffys, P., et al., Eur. J. Biochem. 178: 257 (1988).
Scuderi, P., J. Immunol. 143: 168 (1989).
Masson, D., et al., Cell 49: 679 (1987).
Jenne, D., et al., Proc. Natl. Acad. Sci. USA 85: 4814 (1988).
Pasternack, M. S., et al., Nature 322: 740.12 (1986).
Podack, E. R., et al., J. Exp. Med. 160: 695 (1984).
Gershenfeld, H. K., et al., Science 232: 854 (1986).
Jenne, D., et al., J. Immunol. 140: 318 (1988).
Lobe, C. G., et al., Science 232: 858 (1986).
Gershenfeld, H. K., et al., PNAS USA 85: 1184 (1988).
Dennert, G., et al. Proc. Natl. Acad. Sci. USA 84: 5004 (1987).
Altieri et al. J. Biol. Chem. 264 (5): 2969 (1989).
Altieri et al. J. Immun. 145: 246 (1990).
Molecular Cloning: A Lab Manual, vol. 2, Sambrook et al (Eds). 1989 pp. 8.3, 8.11-22, 8.46-8.51, 10.2-10.12, 11.5-11.12.
Matsudaira, Methods in Enzymology 182: 602-614 (1990).
Cornelissen, et al., Nucl. Acids Res. 14: 2157-2169 (1986).
McGeoch, et al., J. Gen. Virol. 69: 1531-1574 (1988).
Sibold, et al., Mol. Gen. Genetics 214: 439-450 (1988).
Gerard, Meth. Enzymol. 182: 529-539 (1990).
Ostrove, Meth. Enzymol. 182: 357-379 (1990).
Lewin, Genes, John Wiley & Sons, N.Y., 1987, p. 104.
Altieri, et al., "Regulated CA.sup.2+ Signalling Through Leukocyte CD11b/CD18 Integrin", Biochem, J. 288: 465-473 (1992).
Worfolk, et al., "Factor Xa Interacts With Two Sites on Monocytes With Different Functional Activities", Blood 80: 1989-1997 (1992).
Bar-Shavit, et al., "Chemotactic Response of Monocytes to Thrombin", J. Cell. Biol. 96: 282-285 (1983).
Schwartz, "Costimulation of T Lymphocytes: The Role of CD28, CTLA-4, and B7/BB1 in Interleukin-2 Production and Immunotherapy", Cell 71: 1065-1068 (1992).
Stubbs, et al., "cDNA Cloning of a Mouse Mammary Epithelial Cell Surface Protein Reveals the Existence of Epidermal Growth Factor-Like to Domains Linked Factor VIII-Like Sequences", PNAS USA 87: 8417-8421 (1990).
Weber, et al., "Activation Through CD3 Molecule Leads to Clonal Expansion of all Human Peripheral Blood T Lymphocytes: Functional Analysis of Clonally Expanded Cells", J. Immunol. 135: 2337-2342 (1985).
Geppert, et al., "Accessory Cell Independent Proliferation of Human T4 Cells Stimulated By Immobilized Monoclonal Antibodies to CD3", J. Immunol. 138: 1660-1666 (1987).
Chan, et al., "New Insights Into T-Cell Antigen Receptor Structure and Signal Transduction", Curr. Opin. Immunol. 4:246-251 (1992).
Janeway, "The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation", Ann. Rev. Immunol. 10: 645-674 (1992).
Lefranc, et al., "Two Tandemly Organized Human Genes Encoding the T-Cell .gamma. Constant-Region Sequences Show Multiple Rearrangement in Different T-Cell Types", Nature 316: 464-466 (1985).
Brenner, et al., "Two Forms of the T-Cell Receptor .gamma. Protein Found on Peripheral Blood Cytotoxic T Lymphocytes", Nature 325: 689-694 (1987).
Fitting Thomas
Holmes Emily
Schwadron Ronald B.
The Scripps Research Institute
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