Epoxysuccinyl amino acid derivatives

Details Epoxysuccinyl amino acid derivatives Epoxysuccinyl amino acid derivatives

1981-11-10

1983-11-29

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

549549, C07D30348, A61K 31335

Patent

active

044180756

ABSTRACT:
An epoxysuccinyl amino acid derivative of the formula ##STR1## wherein R.sup.1 is hydrogen or alkali metal, R.sup.2 is isobutyl, R.sup.3 is hydrogen or benzyloxycarbonyl, and n is an integer of 5 to 7. The subject compounds exhibit inhibitory activity towards thiol protease, especially, calcium-activated neutral thiol protease which exists in excess in muscle tissues of mammals afflicted with muscular dystrophy.

REFERENCES:
patent: 3911111 (1975-10-01), Sawada et al.
patent: 4064241 (1977-12-01), Ross et al.
Hanada et al., Agric. Biol. Chem., vol. 42(3) (1978) pp. 537-541, and pp. 529-536.
Hanada et al., Agric. Biol. Chem., vol. 42(3) (1978) pp. 529-536.
Chemical Abstracts, vol. 87: 68128z; 68129a; 85238c; 202108y; 202125b.

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