Epoxysuccinyl amino acid derivatives

Details Epoxysuccinyl amino acid derivatives Epoxysuccinyl amino acid derivatives

1980-05-13

1984-10-02

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

549549, C07D30348, A61K 31335

Patent

active

044748000

ABSTRACT:
An epoxysuccinyl amino acid derivative of the formula ##STR1## wherein R.sup.1 is hydrogen, alkali metal, benzyl or cycloalkyl having 5 to 6 carbon atoms, R.sup.2 is alkyl having 3 to 4 carbon atoms, R.sup.3 is hydrogen, benzyloxycarbonyl, acetyl or benzoyl, and n is an integer of 2 to 7. The subject compounds exhibit inhibitory activity towards thiol protease, especially, calcium-activated neutral thiol protease which exists in excess in muscle tissues of mammals afflicted with muscular dystrophy.

REFERENCES:
patent: 3911111 (1975-10-01), Sawada et al.
patent: 4064241 (1977-12-01), Ross et al.
K. Hanada et al., Agric. Biol. Chem., vol. 42(3), (1978), pp. 529-536; 537-541.
Chemical Abstracts, vol. 87: 68128z; 68129a; 85238c; 202108y; 202125b.

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