Epoxysuccinic acid derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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542427, 548336, 548372, 549 60, 549435, 549473, C07D30348, C07D40712, C07D41112, C07D40702

Patent

active

043932282

ABSTRACT:
The epoxysuccinic acid derivatives of this invention are prepared by esterification of an epoxysuccinic acid or a halide thereof, by partial hydrolysis of an epoxysuccinic acid diester, by amidation of an epoxysuccinic acid monoester, or by hydrolysis of an epoxysuccinic acid amide monoester. These epoxysuccinic acid derivatives have excellent thiol protease inhibitory activity and anti-inflammatory activity without the acceleration of vascular permeability.

REFERENCES:
patent: 3911111 (1975-10-01), Sawada et al.
patent: 4064241 (1977-12-01), Ross
K. Hanada et al., Agric. Biol. Chem., vol. 42(3) (1978), pp. 523-536.
Edward B. Roche, Design of Biopharmaceutical Properties through Prodrugs and Analogs (American Pharmaceutical Assoc.), (1977), pp. 346-347.

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