Epoxysuccinamic acid compounds

Details Epoxysuccinamic acid compounds Epoxysuccinamic acid compounds

1981-05-14

1983-06-07

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549473, 549 60, 544374, 544147, 544 587, 546268, 546159, 546171, 546207, 548517, 424278, 424275, 424285, 424263, 424258, 424250, 42424855, 424246, 424274, 424267, C07D30348, C07D40712, C07D40912, C07D40512, C07D40510, C07D41306, C07D40506

Patent

active

043872387

ABSTRACT:
The epoxysuccinamic acid compounds of the present invention are prepared by reaction of monoesters of epoxysuccinic acid or monoesters of epoxysuccinic acid chloride with amino compounds. These epoxysuccinamic acid compounds have excellent anti-inflammatory activity, thiol protease inhibitory activity, muscular dystrophy inhibitory activity and anti-hypertensive activity without acceleration of vascular permeability.

REFERENCES:
patent: 3911111 (1975-10-01), Sawada et al.
patent: 4064241 (1977-12-01), Ross et al.
patent: 4091221 (1978-05-01), Carr et al.
S. M. Creighton et al., Canadian Journal of Chemistry, vol. 45, (1967), pp. 1304-1306.
Edward B. Roche, Design of Biopharmaceutical Properties Through Prodrugs and Analogs, (1977), pp. 346-347.
Chemical Abstracts, vol. 87, 202108y; 85238c; 202125b; 68129a; 68128z.
K. Hanada et al., Agric. Biol. Chem., vol. 42(3), pp. 523-528, 529-536, 537-541 (1978).
C & En., Aug. 18, 1975, p. 27.

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