Epoxypropylphosphonate salt of jesamycin and pharmaceutical comp

Details Epoxypropylphosphonate salt of jesamycin and pharmaceutical comp Epoxypropylphosphonate salt of jesamycin and pharmaceutical comp

1984-10-09

1986-08-19

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 71, 536117, A61K 3171, C07H 1708

Patent

active

046070249

ABSTRACT:
A new salt of the macrolide antibiotic Josamycin with (-)-cis-1,4-epoxypropionylphosphonic acid, of formula (I) ##STR1## The salt (I), prepared from Josamycin base and phosphomycin, possesses favorable antimicrobial and pharmacokinetics properties.

REFERENCES:
patent: 3959252 (1976-05-01), Osono et al.
patent: 4001399 (1977-01-01), Osono et al.
"The Merck Index", published by Merck & Co., Inc., 1976, p. 4110.

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