Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-05-07
1992-04-21
Evans, J. E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
435123, 4352525, 549546, A61K 3112, A61K 31335, C07D30336
Patent
active
051068680
ABSTRACT:
Compounds UCF1 and derivatives thereof exhibit anti-bacterial and anti-tumor activities and may be used for the preparation of anti-bacterial and anti-tumor agents.
Compounds UCF1 may be produced by fermentation of a microorganism of the genus Streptomyces capable of producing compounds UCF1, preferably Streptomyces sp. UOF1 (FERM BP-2844) and recovering the desired compounds from the cultured broth.
The compounds UCF1 have the formula ##STR1## wherein R represents either ##STR2## The compounds may be oxidized to obtain derivatives of formula ##STR3## which exhibit similar pharmacological activities.
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The Journal of Antibiotics 1530, The Structure of Manumycin (Nov. 1987).
16 International Journal of Systematic Bacteriology 313-340, E. B. Shirling and D. Gottlieb, Methods for Characterization of Streptomyces Species (Jul. 1966).
110 Chemical Abstracts 4225, Ralph Grote, et al., Metabolic Products of Microorganisms 244 (Jan. 2, 1989).
110 Chemical Abstracts 4225, Ralph Grote, et al., Metabolic Products of Microorganisms 245 (Jan. 2, 1989).
Hara Mitsunobu
Ikuina Yoji
Nakano Hirofumi
Okabe Masami
Saito Yutaka
Evans J. E.
Kyowa Hakko Kogyo Kabushiki Kaisha
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