Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1977-10-03
1979-01-30
Tovar, Jose
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544 28, 544 22, A61K 31545, C07D50134, C07D50146
Patent
active
041373120
ABSTRACT:
A series of novel 7-(D-.alpha.-acylaminoarylacetamido)-.DELTA..sup.3 -cephem derivatives have been prepared wherein the acyl moiety contains an epoxy group immediately adjacent to the carbonyl carbon atom. These compounds are useful as antibacterial agents for the treatment of diseases caused by Gram-negative and Gram-positive bacteria. Preferred members include 7-[D-.alpha.-(cis-2-carboxyoxiran-3-carboxamido)phenylacetamido]-3-(1-meth yl-1,2,3,4-tetrazol-5-ylthiomethyl)-.alpha..sup.3 -cephem-4-carboxylic acid and 7-[D-.alpha.-(cis-2-carboxyoxiran-3-carboxamido)phenylacetamido]cephalospo ranic acid. Alternate methods of preparation are provided for these compounds and the principal synthetic route is described in detail.
REFERENCES:
patent: 3879381 (1975-04-01), Sellstedt et al.
patent: 4006230 (1977-02-01), Cox et al.
Ross Barry C.
Shroot Braham
Pfizer Inc.
Tovar Jose
Wheeler David E.
LandOfFree
Epoxy substituted cephalosporin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Epoxy substituted cephalosporin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Epoxy substituted cephalosporin derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1150529