Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1996-04-03
1997-10-07
Zemel, Irina S.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
525 543, 525 59, 525296, 210656, 210660, 210679, 210690, 210692, 436529, 436530, 436531, 435179, 435181, C08F29108, B01D 2032, C08L 5100
Patent
active
056749465
DESCRIPTION:
BRIEF SUMMARY
The invention relates to activated support materials which comprise epoxy-substituted poly(meth)acrylamides, and to the use thereof.
BACKGROUND OF THE INVENTION
Activated support materials are important intermediates in the preparation of support materials for affinity chromatography and for the immobilization of enzymes. In polymer-analogous reactions, furthermore, it is possible to use activated support materials to prepare separating materials for ion exchange chromatography, hydrophobic interaction chromatography, gel permeation chromatography and metal chelate chromatography.
Activated support materials derived from epoxy derivatives of crosslinked poly(meth)acrylates are known. These materials, however, have disadvantages owing to their rigid structure. German Patent Application DE 43 10 964 describes noncrosslinked graft polymers based on epoxy (meth)acrylates. The present invention additionally provides noncrosslinked graft polymers based on epoxy-substituted poly(meth)acrylamides.
SUMMARY OF THE INVENTION
The invention relates to activated support materials based on hydroxyl-containing base supports on whose surfaces polymers are covalently bonded, characterized in that monomer unit, ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 independently of one another are H or CH.sub.3,
The invention relates to processes for the preparation of activated support materials based on hydroxyl-containing base supports on whose surfaces polymers are covalently bonded by graft polymerization, characterized by the process steps of ##STR3## in which R.sup.4 is H or alkyl having 1-5 carbon atoms hydroxyl-containing base support particle in the presence of cerium(IV) ions; and
The invention also relates to the use of an activated support material according to the invention for the preparation of chromatographic separating materials and for the immobilization of enzymes.
The invention relates to processes for the preparation of chromatographic separating materials, characterized in that separation effectors are bonded to activated support materials according to the invention, and to the chromatographic separating materials prepared by these processes.
The invention relates to processes for the preparation of immobilized enzymes, characterized in that enzymes are bonded to activated support materials according to the invention, and to the immobilized enzymes prepared by these processes.
The chlorohydrin-containing alkylamines of the formula II are, where not commercially obtainable, accessible to the person skilled in the art by customary processes. The examples describe one process variant.
Process variants suitable for the acryloylation of the alkylamines of the formula II are familiar to the person skilled in the art. A suitable reaction, for example, is that of Schotten-Baumann and its variants. The acrylic or methacrylic acid derivative employed is preferably the acid chloride. Other suitable derivatives are familiar to the person skilled in the art, examples being the acid azides or anhydrides. Acryloylation is preferably carried out in the presence of a polymerization inhibitor.
Base supports in the context of the present invention are particles, but also materials in the form of membranes or filaments, and also netlike, tissuelike or spongelike materials, on which polymers are grafted. Base supports which can be employed are in general customary, porous or nonporous, support particles, provided they have primary or secondary aliphatic hydroxyl groups at their surface, or can have aliphatic hydroxyl groups introduced into them by methods which are known per se. Suitable supports include, inter alia, agarose-based polysaccharides, cellulose, cellulose derivatives and polymers based on dextran. Preference is given to polyvinyl alcohol-based polymers or copolymers of (meth)acrylate derivatives and comonomers containing aliphatic hydroxyl groups. Particular preference is given to diol-modified silica gels as base supports, and to polyvinyl-based copolymers containing aliphatic hydroxyl groups. Base supports of
REFERENCES:
patent: 4756834 (1988-07-01), Muller
patent: 4914159 (1990-04-01), Bomer
patent: 5096971 (1992-03-01), Nishikaji
patent: 5519064 (1996-05-01), Stringfield
Merck Patent Gesellschaft mit beschrankter Haftung
Zemel Irina S.
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