Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-12-29
1988-11-08
Brown, J. R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549414, 549512, 549554, A61K 31335, C07D30304, C07D30312
Patent
active
047834838
ABSTRACT:
Alkenes of the formula (I) and epoxides (II) used to make them are useful as anti-inflammatory and antiallergic pharmaceuticals: ##STR1## wherein R.sup.1 =H or CH.sub.3 ; R.sup.2 =phenyl, substituted phenyl, benzyl or a cysteinyl moiety; R.sup.4 and R.sup.5 =alkyl; n=O or 1; and R.sup.3 is as described.
REFERENCES:
patent: 4513005 (1985-04-01), Baker et al.
Science, "The Leukotrienes in Allergy and Inflammation", vol. 215, pp. 1380-1383, (1982).
Chest, "Leukotrienes and Other Lipid Mediators of Asthma", Robert A. Lewis, M.D., vol. 87, No. 1, pp. 5S-10S (1985).
Drugs, "Leukotrienes in Disease Implications for Drug Development", G. A. Higgs and S. Moncada, vol. 30, pp. 1-5, (1985).
ACTA Physiologica Scandinavica, "Pulmonary Effects of Leukotrienes", Sven-Erik Dahlen, Stockholm 1983, Supplementum 512, pp. 4-6 and 37-38.
Ferro Michael P.
Wachter Michael P.
Brown J. R.
Davis Wendy B.
Levy David J.
Ortho Pharmaceutical Corporation
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