Epoxide process

Details Epoxide process Epoxide process

1978-07-31

1980-02-19

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26039745, C07J 2100, C07J 500

Patent

active

041894308

ABSTRACT:
11.beta.,21-Dihydroxypregna-1,4,17(20)-triene-3-one 21-acetate (0) is epoxidized, followed by ring opening and hydrolysis to give 11.beta.,20,21-trihydroxypregna-1,4,16-triene-3-one 21-acetate (III), an intermediate in the synthesis of betamethasone, in improved yields.

REFERENCES:
patent: 3281415 (1966-10-01), Schneider et al.
patent: 3375261 (1968-03-01), Arth et al.
patent: 3444216 (1969-05-01), Parikh et al.
patent: 3725392 (1973-04-01), Beal et al.
patent: 3876633 (1975-04-01), Loken

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