Epoxide hydrolases, nucleic acids encoding them and methods...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S018000, C435S252300, C435S325000, C435S410000, C435S254100, C435S255100, C435S320100, C536S023200, C536S024330

Reexamination Certificate

active

06943001

ABSTRACT:
The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.

REFERENCES:
patent: 4558004 (1985-12-01), Hammock et al.
patent: 5387742 (1995-02-01), Cordell
patent: 5445956 (1995-08-01), Hammock et al.
patent: 5573933 (1996-11-01), Seamark et al.
patent: 5605793 (1997-02-01), Stemmer
patent: 5635369 (1997-06-01), Pompon et al.
patent: 5705647 (1998-01-01), Babu et al.
patent: 5759765 (1998-06-01), Harris et al.
patent: 5795737 (1998-08-01), Seed et al.
patent: 5811238 (1998-09-01), Stemmer et al.
patent: 5824514 (1998-10-01), Kauffman et al.
patent: 5830721 (1998-11-01), Stemmer et al.
patent: 5834252 (1998-11-01), Stemmer et al.
patent: 5939250 (1999-08-01), Short
patent: 5955358 (1999-09-01), Huse
patent: 5955496 (1999-09-01), Hammock et al.
patent: 5965408 (1999-10-01), Short
patent: 6037160 (2000-03-01), Wisnewski et al.
patent: 6057103 (2000-05-01), Short
patent: 6143542 (2000-11-01), Wisnewski et al.
patent: 6150415 (2000-11-01), Hammock et al.
patent: 6153397 (2000-11-01), Wisnewski et al.
patent: 6174695 (2001-01-01), Hammock et al.
patent: 6287861 (2001-09-01), Stemmer et al.
patent: 6287862 (2001-09-01), delCardayre et al.
patent: 6291242 (2001-09-01), Stemmer
patent: 6361974 (2002-03-01), Short et al.
patent: 6372469 (2002-04-01), Arahira et al.
patent: 6379938 (2002-04-01), Dauvrin et al.
patent: 6387668 (2002-05-01), Lutje Spelberg et al.
patent: 6537776 (2003-03-01), Short
patent: WO 98/53081 (1988-11-01), None
patent: WO 94/03588 (1994-02-01), None
patent: WO 98/02554 (1998-01-01), None
patent: WO 99/21972 (1999-05-01), None
patent: WO 00/09682 (2000-02-01), None
patent: WO 00/20573 (2000-04-01), None
patent: WO 00/29846 (2000-05-01), None
patent: WO 00/37619 (2000-06-01), None
patent: WO 00/40569 (2000-07-01), None
patent: WO 00/48593 (2000-08-01), None
patent: WO 99/06059 (2000-10-01), None
patent: WO 01/07623 (2001-02-01), None
patent: WO 01/10438 (2001-02-01), None
patent: WO 01/46476 (2001-06-01), None
Misawa, E., et al. (1998) Acc. No. CAJ4332.
Vipey, V., et al. (2000) Acc. No. AZ578947.
Strausberg (2000) Acc. No. BF434120.
Steinreiber, A. and Faber, K., “Microbial epoxide hydrolases for preparative biotransformations”,Curr. Opin. Biotechnol.vol. 12, pp. 552-558, 2001.
Zhi-Xian Wang et al., “An Efficient Catalytic Asymmetric Epoxidation Method,”J. Am. Chem. Soc.vol. 119, pp. 11224-11235, 1997.
Tokunaga, M. Asymmetric Catalysis with Water: Efficient Kinetic Resolution of Terminal Epoxides by Means of Catalytic HydrolysisScience1997, vol. 277, pp. 936-938, 1997.
Morisseau, C.Proc. Natl. Acad. Sci.vol. 96, pp. 8849-8854, 1999.
Swaving, J., “Microbial transformation of epoxices”,Enzyme and Microbial Technology,vol. 22, pp. 19-26, 1998.
Patten, et al., “Applications of DNA shuffling to pharmaceuticals and vaccines”,Current Opinion in Biotechnology,vol. 8, pp. 724-733, 1997.
Nardini, M., “The X-ray Structure of Epoxide Hydrolase fromAgrobacterium radiobacterADl”, vol. 274, No. 21, pp. 14579-14586, 1999.
Ling, M.M., “Approaches to DNA Mutagenesis: An Overview”,Analytical Biochemistry,vol. 254, pp. 157-178, 1997.
Goswami, A., “Stereospecific enzymatic hydrolysis of racemic epoxide: a process for making chiral epoxide”,Tetrahedron:Asymmetry,vol. 10, pp. 3167-3175, 1999.
Genzel, Y., “Microbiological transformations. Part 46: Preparation of enantiopure (S)-2pyridyloxirane via epoxide hydrolase-catalysed kinetic resolution”,Tetrahedron:Asymmetry,vol. 11, pp. 3041-3044, 2000.
Cleij, M., “Microbiological transformatioons. Part 42: A two-liquid-phase preparative scale process for an epoxide hydrolase catalysed resolution of para-bromo-α-methyl styrene oxide. Occurrence of a surprising enantioselectivity enhancement”,Tetrahedron:Asymmetry,vol. 9, pp. 1839-1842, 1998.
Argiriadi, M., “Detoxification of environmental mutagens and carcinogens: Structure, mechanism, and evolution of liver epoxide hydrolase”,Proc. Natl. Acad. Sci.,vol. 96, pp. 10637-10642, 1999.
Archelas, A., “Synthetic applications of epoxide hydrolases”,Current Opinion in Chemical Biology,vol. 5, pp. 112-119, 2001.
Crameri, A., “DNA shuffling of a family of genes from diverse species accelerates directed evolution”,Nature,vol. 391, pp. 288-291, 1998.
Rice, G., “Random PCR mutagenesis screening of secreted proteins by directed expression in mammalian cells”,Proc. Natl. Acad. Sci.,vol. 89, pp. 5467-5471, 1992.
Arkin, A., “An algorithm for protein engineering: Simulations of recursive ensemble mutagenesis”,Proc. Natl. Acad. Sci.,vol. 89, pp. 7811-7815, 1992.
Stemmer, W., “DNA shuffling by random fragmentation and reassembly: In vitro recombination for molecular evolution”,Proc. Natl. Acad. Sci.vol. 91, pp. 10740-10751, 1994.
Orru, R.V.A., “Stereoselectivities of microbial epoxide hydrolases”,Current Opinion in Chemical Biology,vol. 3, pp. 16-21, 1999.
Weijers, C.A.G.M., Enantioselective hydrolysis of unbranched aliphatic 1,2-epoxides byRhodotorula glutinis, Tetrahedron:Asymmetry,vol. 9, pp. 467-473, 1998.
Weijers, C.A.G.M., “Enantiselective hydrolysis of aryl, alicyclic and aliphatic epoxides byRhodotorula glutinis”, Tetrahedron:Asymmetry,vol. 8, No. 4, pp. 639-647, 1997.
Wu, M., “An Efficient Formal Synthesis of Balanol via the Asymmetric Epoxide Ring Opening Reaction”,Tetrahedron Letters,vol. 38, No. 10, pp. 1693-1696, 1997.
Kim, B.M., “Synthesis of a Chiral Aziridine Derivative as a Versatile Intermediate for HIV Protease Inhibitors”,Organic Letters,vol. 3, No. 15, pp. 2349-2351, 2001.
Jacobsen, E.N., “Asymmetric Catalysis of Epoxide Ring-Opening Reactions”,Acc. Chem. Res.,vol. 33, pp. 421-431, 2000.
Schaus, S. E., Dynamic Kinetic Resolution of Epichlorohydrin via Enantioselective Catalytic Ring Opening with TMSN3, Practical Synthesis of Aryl Oxazolidinone Antibacterial Agents,Tetrahedron Letters,vol. 37, No. 44, pp. 7937-7940, 1996.
Xu, Z., “Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-23632”,Organic Process Research&Development,vol. 6, pp. 323-328, 2002.
Ikunaka, M., “A Process in Need is a Process Indeed: Scalable Enantioselective Synthesis of Chiral Compounds for the Pharmaceutical Industry”,Chem. Eur. M.,vol. 9, No. 2, pp. 378-388, 2003.
Yu, D., “Synthesis and Antibacterial Activity of Linezolid Analogues”,Bioorganic&Medicinal Chemistry Letters,vol. 12, pp. 857-859, 2002.
Hechtberger, P., “Asymmetric Hydrolysis of Epoxides using an Immobilized Enzyme Preparation fromPhodococcussp.”,Tetrahedron:Asymmetry,vol. 4, No. 6, pp. 1161-1164, 1993.
Spelberg, J.H.L., “Biocatalytic Potential of the Epoxide Hydolase fromAgrobacterium radiobacterADl and a Mutant with Enhanced Enantioselectivity”,Adv. Synth. Catal.,vol. 344, No. 9, pp. 980-985, 2002.
Sagawa, S., “Catalytic Asymmetric Aminolysis of 3,5,8-Trioxabicyclo [5.1.0] octane Providing an Optically Pure 2-Amino-1,3,4-butanetriol Equivalent”,J. Org. Chem.,vol. 64, pp. 4962-4965, 1999.
Zook, S., “A concise synthesis of the HIV-protease inhibitor nelfinavir via an unusual tetrahydrofuran rearrangement”,Tetrahedron Letter,vol. 41, pp. 7017-7021, 2000.
Inaba, T., “A Practical Synthesis of Nelfinavir, an HIV-Protease Inhibitor, Using a Novel Chiral C4 Building Block: (5R,6S)-2,2-Dimethyl-5-hydroxy-1,3-dioxepan-6-ylammonium Acetate”,J. Org. Chem.,vol. 64, pp. 7582-7583, 1998.
Weijers, C.A.G.M., “Epoxide hydrolase from yeasts and other sources, versatile tools in biocatalysis”,Journal of Molecular Catalysis B-Enzymatic,v

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Epoxide hydrolases, nucleic acids encoding them and methods... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Epoxide hydrolases, nucleic acids encoding them and methods..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Epoxide hydrolases, nucleic acids encoding them and methods... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3401539

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.