Epothilones C, D, E, and F, preparation and compositions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C548S204000

Reexamination Certificate

active

07846952

ABSTRACT:
The present invention relates to epothilones C, D, E, and F, their preparation and their use for the production of therapeutic compositions and compositions for plant protection.

REFERENCES:
patent: 5057529 (1991-10-01), Wilson et al.
patent: 5665767 (1997-09-01), Fischer et al.
patent: 6194181 (2001-02-01), Hofmann et al.
patent: 6204388 (2001-03-01), Danishefsky et al.
patent: 6211412 (2001-04-01), Georg et al.
patent: 6252094 (2001-06-01), Nicolaou et al.
patent: 6262094 (2001-07-01), Hoefle et al.
patent: 6288237 (2001-09-01), Hoefle et al.
patent: 6316630 (2001-11-01), Danishefsky et al.
patent: 6359140 (2002-03-01), Hofle et al.
patent: 6380394 (2002-04-01), Nicolaou et al.
patent: 6410301 (2002-06-01), Julien et al.
patent: 6441186 (2002-08-01), Nicolaou et al.
patent: 6489314 (2002-12-01), Ashley et al.
patent: 6531497 (2003-03-01), Nicolaou et al.
patent: 6537988 (2003-03-01), Lee
patent: 6589968 (2003-07-01), Arslanian et al.
patent: 6596875 (2003-07-01), White et al.
patent: 6605599 (2003-08-01), Vite et al.
patent: 6613912 (2003-09-01), Hoefle et al.
patent: 6624310 (2003-09-01), Hoefle et al.
patent: 6656961 (2003-12-01), Danishefsky et al.
patent: 6660758 (2003-12-01), Nicolaou et al.
patent: 6730803 (2004-05-01), Iwasaki et al.
patent: 6780620 (2004-08-01), Li et al.
patent: 6884608 (2005-04-01), Basch et al.
patent: 6906188 (2005-06-01), White et al.
patent: 6921769 (2005-07-01), Danishefsky et al.
patent: 7067544 (2006-06-01), Hoefle et al.
patent: 7235669 (2007-06-01), Hoefle et al.
patent: 2003/0187039 (2003-10-01), Favreau et al.
patent: 2004/0087634 (2004-05-01), Hoefle et al.
patent: 2004/0127432 (2004-07-01), Nicolaou et al.
patent: 2004/0132146 (2004-07-01), Benigni et al.
patent: 2004/0176429 (2004-09-01), Li et al.
patent: 716610 (1998-03-01), None
patent: 1330203 (1994-06-01), None
patent: 4138042.8 (1993-05-01), None
patent: 19542986.9 (1997-05-01), None
patent: 19639456.2 (1997-05-01), None
patent: 19636343.8 (1998-03-01), None
patent: 19645361.5 (1998-04-01), None
patent: 19645362.3 (1998-04-01), None
patent: 19647580.5 (1998-05-01), None
patent: 19701758 (1998-07-01), None
patent: 19707505.3 (1998-09-01), None
patent: 19713970 (1998-10-01), None
patent: 19720312 (1998-11-01), None
patent: 19821954 (1998-11-01), None
patent: 19726627 (1998-12-01), None
patent: 879 605 (1998-11-01), None
patent: 0 903 348 (1999-03-01), None
patent: 0 941 227 (1999-09-01), None
patent: 1 186 606 (2002-03-01), None
patent: 2000-500757 (2000-01-01), None
patent: 2001-500851 (2001-01-01), None
patent: 93/10121 (1993-05-01), None
patent: 97/19086 (1997-05-01), None
patent: 98/08849 (1998-03-01), None
patent: 98/22461 (1998-05-01), None
patent: 98/24427 (1998-06-01), None
patent: 98/25929 (1998-06-01), None
patent: 98/38192 (1998-09-01), None
patent: 98/47891 (1998-10-01), None
patent: 99/01124 (1999-01-01), None
patent: 99/02514 (1999-01-01), None
patent: 99/03848 (1999-01-01), None
patent: 99/07692 (1999-02-01), None
patent: 99/39694 (1999-08-01), None
patent: 99/42602 (1999-08-01), None
patent: 99/43320 (1999-09-01), None
patent: 99/43653 (1999-09-01), None
patent: 99/67252 (1999-12-01), None
patent: 00/00485 (2000-01-01), None
patent: 00/31247 (2000-06-01), None
patent: 00/37473 (2000-06-01), None
patent: 00/49021 (2000-08-01), None
patent: 00/66589 (2000-11-01), None
Corey, et al.; “Efficient and Mild lactonization Method for the Synthesis of Macrolides”; J. Am. Chem. Soc., 1974, 96 (17), 5614-5616.
Kruizinga, et al.; “Preparation of Macrocyclic Lactones by Ring Closure of Cesium Carboxylates”; J. Am. Chem. Soc., 1981, 103 (17), 5183-5189.
Inanaga, et al.; “A Rapid Esterification by Means of Mixed Anhydride and Its Application to Large-ring Lactonization”; Bull. Chem. Soc. Japan, vol. 52 (7), 1989-1993 (1979).
Lau, et al., “Optimizing the Heterologous Production of Epothilone D in Myxococcus xanthus”, Biotech. & Bioengin., vol. 78, No. 3 (2002) 280-88.
Gerth, et al., “Studies on the Biosynthesis of Epothilones: The PKS and Epothilone C/D Monooxygenase”, J. Antibiot., vol. 54, No. 2 (2001) 144-48.
Molnar et al., “The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B fromSorangium cellulosumSo ce90”, Chemistry & Biology, vol. 7, No. 2 (2000) 97-109.
Tang et al., “Cloning and Heterologous Expression of the Epothilone Gene Cluster”, Science, vol. 287 (2000) 640-42.
Hardt et al., “New Natural Epothilones fromSorangium cellullosum, Strains So ce90/B2 and So ce90/D13: Isolation, Structure Elucidation, and SAR studies”, J. Nat. Prod., vol. 64, No. 7 (2001) 847-56.
U.S. Appl. No. 08/856,533, filed May 14, 1997, Nicolaou, K., et al.
U.S. Appl. No. 08/923,869, filed Sep. 4, 1997, Nicolaou, K., et al.
U.S. Appl. No. 60/032,864, filed Dec. 13, 1996, Nicolaou, K., et al.
Balog, A., et al., “Total Synthesis of (−)-Epothilone A”,Angew. Chem. Int. Ed. Engl., vol. 35, No. 23/24, 2801-2803 (1996).
Bertini, F., et al., “Alkenes from Epoxides by Reductive Elimination with Magnesium Bromide-Magnesium Amalgam”,Chem. Commun. ,144 (1970).
Bollag, D.M., et al., “Epothilones, A New Class of Microtubule-stabilizing Agents with a Taxol-like Mechanism of Action”,Cancer Res. 55, No. 11, 2325-2333 (1995).
Fujisawa, T., et al., “Deoxygenation of Epoxides to Olefins with FeCl3—n-BuLi System”,Chem. Lett., 883-886 (1974).
Fujiwara, Y., et al., “Reductive Coupling of Carbonyl Compounds to Olefins by Tungsten Hexachloride-Lithium Aluminum Hydride and Some Tungsten and Molybdenum Carbonyls”,J. Org. Chem., vol. 43, No. 12, 2477-2479 (1978).
Gladysz, J. A., et al., “Deoxygenation of Epoxides by Metal Atom. Cocondensation”,J. Org. Chem., vol. 41, No. 22, 3647-3648 (1976).
Hofle, G., et al., “Epothilone A and B—Novel 16-Membered Macrolides Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution”,Angew. Chem. Int. Ed. Engl., vol. 35, No. 13/14, 1567-1569 (1996).
Hofle, G., et al., “N-Oxidation of Epothilone A-C and O-Acyl Rearrangement to C-19 and C-21 -Substituted Epothilones”,Angew. Chem. Int. Ed., vol. 38, No. 13/14, 1971-1974 (1999).
Inokuchi, T., et al., “Opening of Epoxides to Olefins or Halohydrins with Vanadium(II)-Tetrahydrofuran or Vanadium(III)-Tetrahydrofuran Complexes”,Synlett, No. 6, 510-512 (1992).
Kowalski. R. J., et al., “Activities of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)”J. Biol. Chem., vol. 272, No. 4, 2534-2541 (1997).
Kupchan, S. M., et al., “Reductive Elimination of Epoxides to Olefins with Zinc-Copper Couple”,J. Org. Chem., vol. 36, No. 9, 1187-1190 (1971).
Martin, M. G., et al., “Epoxides as Alkene Protecting Groups. A Mild and Efficient Deoxygenation”,Tetrahedron Letters, vol. 25, No. 3, 251-254 (1984).
McMurry, J. E., et al., “Reduction of Epoxides to Olefins with Low Valent Titanium”,J. Org. Chem., vol. 40, No. 17, 2555-2556 (1975).
McMurry, J. E., et al., “Some Deoxygenation Reactions with Low-Valent Titanium (TiCl3/LiAlH4)”,J. Org. Chem., vol. 43, No. 17, 3249-3254 (1978).
Meng, D., et al., “Remote Effects in Macrolide Formation Through Ring-Forming Olefin Metathesis: An Application to the Synthesis of Fully Active Epothilone Congeners”,J. Am. Chem. Soc., vol. 119, No. 11, 2733-2734 (1997).
Nicolaou, K. C., et al., “An Approach to Epothilones Based on Olefin Metathesis”,Angew. Chem. Int. Ed. Engl., vol. 35, No. 20, 2399-2401 (1996).
Nicolaou, K. C., et al., “Total Synthesis of Epothilone A: The Macrolactonization Approach”,Angew. Chem. Int. Ed. Engl., vol. 36, No. 5, 525-527 (1997).
Nicolaou, K. C., et. al., “Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, and Cytotoxic Action against Taxol-Resistant Tumor Cells”,Angew

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Epothilones C, D, E, and F, preparation and compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Epothilones C, D, E, and F, preparation and compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Epothilones C, D, E, and F, preparation and compositions will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4225380

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.