Epothilone minor constituents

Details Epothilone minor constituents Epothilone minor constituents

2001-03-21

2003-09-23

Gerstl, Robert (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06624310

ABSTRACT:

The invention concerns compounds which in the present context are designated epothilone side components, viz. compounds 5 to 13 and 16 to 39. These compounds can be produced by fermenting DSM 6773 in accordance to DE 41 38 042.8.
Characterizing data of the compounds according to the invention will be compiled as follows.
Production: The processing of a raw epothilone mixture, which has been produced by fermenting DSM 6773 in a 900 l fermentor, can be drawn schematically from
FIGS. 1
to
2
.


REFERENCES:
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Nicolaou et al., 1998, “Chemical Biology of Epothilones”, Angew. Chem. Int. Ed. 37:2014-2045.

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