Epothilone derivatives and methods for making and using the...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C540S461000, C540S462000, C540S463000

Reexamination Certificate

active

10845467

ABSTRACT:
This invention relates to compounds of formula (I)and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the treatment of diseases or conditions characterized by cellular hyperproliferation. This invention also relates to means for the preparation of compounds of formula (I); formulations containing compounds of formula (I); and methods for the use of said compounds and formulations in the treatment of a disease or condition characterized by cellular hyperproliferation, including cancer.

REFERENCES:
patent: 5415869 (1995-05-01), Straubinger et al.
patent: 5424073 (1995-06-01), Rahman et al.
patent: 5510118 (1996-04-01), Bosch et al.
patent: 5534270 (1996-07-01), De Castro
patent: 5662883 (1997-09-01), Bagchi et al.
patent: 5683715 (1997-11-01), Boni et al.
patent: 5886026 (1999-03-01), Hunter et al.
patent: 6120847 (2000-09-01), Yang et al.
patent: 6156373 (2000-12-01), Zhong et al.
patent: 6302838 (2001-10-01), O'Reilly et al.
patent: 6303342 (2001-10-01), Julien et al.
patent: 6359140 (2002-03-01), Hoefle et al.
patent: 6365749 (2002-04-01), Kim et al.
patent: 6383787 (2002-05-01), Schupp et al.
patent: 6410301 (2002-06-01), Julien et al.
patent: 6489314 (2002-12-01), Ashley et al.
patent: 6589968 (2003-07-01), Arslanain et al.
patent: 2003/0073205 (2003-04-01), Arslanian et al.
patent: 2003/0096381 (2003-05-01), Julien et al.
patent: 2003/0144523 (2003-07-01), Klar et al.
patent: WO 93/10121 (1993-05-01), None
patent: WO 97/19086 (1997-05-01), None
patent: WO 98/22461 (1998-05-01), None
patent: WO 98/24427 (1998-06-01), None
patent: WO 98/30205 (1998-07-01), None
patent: WO 99/02514 (1999-01-01), None
patent: WO 99/07692 (1999-02-01), None
patent: WO 99/39694 (1999-08-01), None
patent: WO 99/42602 (1999-08-01), None
patent: WO 99/43653 (1999-09-01), None
patent: WO 99/65913 (1999-12-01), None
patent: WO 00/00485 (2000-01-01), None
patent: WO 00/31247 (2000-06-01), None
patent: WO 00/39276 (2000-07-01), None
patent: WO 00/50423 (2000-08-01), None
patent: WO 00/71163 (2000-11-01), None
patent: WO 01/10412 (2001-02-01), None
patent: WO 01/83800 (2001-11-01), None
patent: WO 02/80846 (2002-10-01), None
U. S. Appl. No. 10/115,198, filed Apr. 2, 2002, Ashley et al.
Borzilleri et al., “A Novel Application of a Pd(0)-Catalyzed Nucleophilic Substitution Reaction to the Regio- and Stereoselective Synthesis of Lactam analogues of the Epothilone Natural Products, ”J. Am. Chem. Soc., 122:8890-8897 (2000).
Gerth et al., “Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties,”J. Antibiot. (Tokyo), 49(6):560-563.
Giannakakou et al., “Combinations of paclitaxel and vinblastine and their effects on tubulin polymerization and cellular cytotoxicity: characterization of a synergistic schedule,”Int. J. Cancer, 75(1):57-63 (1998).
Giannakakou et al., “Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitazel-driven polymerization,”J. Biol. Chem., 272(27):17118-17125 (1997).
Hofle et al., “Epothilone A and B—Novel 16 Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution,”Agnew, Chem. Int. Ed. Engl., 35(13/14):1567-1569 (1996).
International Search Report mailed Sep. 23, 2003 for PCT application No. PCT/US02/10468 filed Apr. 2, 2002, 7 pages.
Skehan et al., “New colorimetric cytotoxicity assay for anticancer-drug screening,”J. Natl. Cancer Inst.,82(13):1107-1112 (1990).
Tang et al., “Cloning and heterologous expression of the epothilone gene cluster,”Science, 287(5453):64-642 (2000).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Epothilone derivatives and methods for making and using the... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Epothilone derivatives and methods for making and using the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Epothilone derivatives and methods for making and using the... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3842831

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.