Epothilone derivatives, a method for the production thereof,...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C549S270000, C549S213000, C549S271000

Reexamination Certificate

active

06982280

ABSTRACT:
The present invention relates to epothilon derivatives, processes for their production and their use in the manufacture of medicaments and plant protection agents.

REFERENCES:
patent: 6380394 (2002-04-01), Nicolaou et al.
patent: DEX 195 42 986 (1997-05-01), None
patent: WO 93/10121 (1993-05-01), None
patent: WO/97/19086 (1997-05-01), None
patent: WO 98/22461 (1998-05-01), None
patent: WO 99/67252 (1999-12-01), None
Nicolaou, K.C. et al. : Total synthesis of Oxazole- and cyclopropane-containing Epothilone B analouges by the macrolactonization approach. Chem Eur. J. vol. 3, pp. 1971-19896, 1997.
U.S. Appl. No. 08/856,533, filed 05/14/97, Nicolaou et al.
Balog et al., 1996, “Total Synthesis of (-)-Epothilone A”, Angew. Chem. Int. Ed. Engl. 35:2801-2803.
Gerth et al., 1996, “Epothilons A and B: Antifungal and Cytotoxic Compounds fromSorangium cellulosum(Myxobacteria) Production, Physico-chemical and Biological Properties”, J. of Antibiotics 49:560-563.
Hofle et al., 1996, “Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution”, Angew. Chem. Int. Ed. 35:1567-1569.
Hofle et al., 1999, “N-Oxidation of Epothilone A-C and O-Acyl Rearrangement to C-19 and C-21 Substituted Epothilones”, Angew. Chem. Int. Ed. 38:1971-1974.
Nicolaou et al., 1997, “Total Synthesis of Oxazole- and Cyclopropane-Containing Epothilone B Analouges by the Macrolactonization Approach”, Chem. Eur. J. 3:1971-1986.
Nicolaou et al., 1998, “Total Synthesis of Epothilone E and Analouges with Modified Side Chain Reactions through the Stille Coupling Reaction”, Angew. Chem. Int. Ed. 37:84-87.
Nicolaou et al., 1997, “Designed Epothilones; Combinatorial Synthesis, Tubulin Assembly Properties, and Cytotxic Action against Taxol-Resistant Tumor Cells”, Angew. Che. Int. Ed. Engl. 36:2097-2103.
Nicolaou et al., 1997, “Total synthesis of Oxazole- and Cyclopropane-Containing Epothilone A Analogues by the Olefin Metathesis Approach”, Chem. Eur. J. 3: 1957-1970.

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