Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-07-10
2007-07-10
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S365000, C514S366000, C514S450000, C540S452000, C540S462000, C540S463000, C540S468000, C548S202000, C548S203000, C549S346000, C549S355000
Reexamination Certificate
active
11512623
ABSTRACT:
The present invention relates to compounds of the formulain which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7are as defined herein, methods for the preparation of the derivatives and intermediates thereof.
REFERENCES:
patent: 4272525 (1981-06-01), Wright
patent: 4820695 (1989-04-01), Debono et al.
patent: 5545624 (1996-08-01), Hecker et al.
patent: 5610178 (1997-03-01), Zeeck et al.
patent: 5716939 (1998-02-01), Lundy et al.
patent: 5760011 (1998-06-01), Jaynes et al.
patent: 5763429 (1998-06-01), Bishop et al.
patent: 5786348 (1998-07-01), Bishop et al.
patent: 5795882 (1998-08-01), Bishop et al.
patent: 5798345 (1998-08-01), Knutson et al.
patent: 6124453 (2000-09-01), Fehr et al.
patent: 6194181 (2001-02-01), Hofmann et al.
patent: 6204388 (2001-03-01), Danishefsky et al.
patent: 6211412 (2001-04-01), Georg et al.
patent: 6242469 (2001-06-01), Danishefsky et al.
patent: 6316630 (2001-11-01), Danishefsky et al.
patent: 6365749 (2002-04-01), Kim et al.
patent: 6369234 (2002-04-01), Danishefsky et al.
patent: 6380394 (2002-04-01), Nicolaou et al.
patent: 6441186 (2002-08-01), Nicolaou et al.
patent: 6518421 (2003-02-01), Li et al.
patent: 6576651 (2003-06-01), Bandyopadhyay et al.
patent: 6605599 (2003-08-01), Vite et al.
patent: 6656961 (2003-12-01), Danishefsky et al.
patent: 6670384 (2003-12-01), Bandyopadhyay et al.
patent: 6686380 (2004-02-01), Lee
patent: 6689802 (2004-02-01), DiMarco et al.
patent: 6867305 (2005-03-01), Danishefsky et al.
patent: 2002/0143038 (2002-10-01), Bandyopadhyay
patent: 2003/0073677 (2003-04-01), Lee
patent: 4138042.8 (1993-05-01), None
patent: 4316836 (1994-11-01), None
patent: 19542986.9 (1997-05-01), None
patent: 19639456.2 (1997-05-01), None
patent: 19636343.8 (1998-03-01), None
patent: 19645361.5 (1998-04-01), None
patent: 19645362.3 (1998-04-01), None
patent: 19647580.5 (1998-05-01), None
patent: 19701758 (1998-07-01), None
patent: 19707505.3 (1998-09-01), None
patent: 19713970 (1998-10-01), None
patent: 19720312 (1998-11-01), None
patent: 19821954 (1998-11-01), None
patent: 19726627 (1998-12-01), None
patent: 0 103 465 (1984-03-01), None
patent: 0 512 779 (1992-11-01), None
patent: 0 586 738 (1994-03-01), None
patent: 0 606 747 (1994-07-01), None
patent: 0 778 283 (1997-06-01), None
patent: 0 879 605 (1998-11-01), None
patent: 3101679 (1991-04-01), None
patent: WO 92/19247 (1992-11-01), None
patent: WO 93/10121 (1993-05-01), None
patent: WO 94/13324 (1994-06-01), None
patent: WO 94/21657 (1994-09-01), None
patent: WO 95/02594 (1995-01-01), None
patent: WO 96/09312 (1996-03-01), None
patent: WO 96/11398 (1996-04-01), None
patent: WO 96/26182 (1996-08-01), None
patent: WO 97/19086 (1997-05-01), None
patent: WO 97/19088 (1997-05-01), None
patent: WO 98/08849 (1998-03-01), None
patent: WO 98/22461 (1998-05-01), None
patent: WO 98/22462 (1998-05-01), None
patent: WO 98/24427 (1998-06-01), None
patent: WO 98/25929 (1998-06-01), None
patent: WO 98/38192 (1998-09-01), None
patent: WO 98/47891 (1998-10-01), None
patent: WO 99/01124 (1999-01-01), None
patent: WO 99/03848 (1999-01-01), None
patent: WO 99/07692 (1999-02-01), None
patent: WO 99/39694 (1999-08-01), None
patent: WO 99/42602 (1999-08-01), None
patent: WO 99/43320 (1999-09-01), None
patent: WO 99/43653 (1999-09-01), None
patent: WO 99/67252 (1999-12-01), None
patent: WO 00/00485 (2000-01-01), None
patent: WO 00/31247 (2000-06-01), None
patent: WO 00/37473 (2000-06-01), None
patent: WO 00/49021 (2000-08-01), None
patent: WO 00/66589 (2000-11-01), None
Balog et al., 1996, “Total Synthesis of (−)-Epothilone A”, Angew. Chem. Int. Ed. Engl., 35(23-24):2801-2803.
Bertini et al., 1970, “Alkenes from Expoxides by Reductive Elimination with Magnesium Bromide-Magnesium Amaigam”, Chem. Commun., 144.
Bollag et al., 1995, “Epothilones, A New Class of Microtubule-stabilizing Agents with a Taxol-like Mechanism of Action”, Cancer Res. 55, No. 11, 2325-2333.
Fujisawa et al., 1974, “Deoxygenation of Epoxides to Olefins with FeCl3——BuLi System”, Chem. Lett., 883-886.
Fujisawa et al., 1978, “Reductive Coupling of Carbonyl Compounds to Olefins by Tungsten Hexachloride-Lithium Aluminum Hydride and Some Tungsten and Molybdenum Carbonyls”, J. Org. Chem., 43(12): 2477-2479.
Gladysz et al., 1976, “Deoxygenation of Epoxides by Metal Atom Cocondensation”, J. Org. Chem., 41(22): 3647-3648.
Hofle et al., 1996, “Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution”, Angew. Chem. Int. Ed Engl., 35(13-14):1567-1569.
Hofle et al., 1999, “N-Oxidation of Epothilone A-C and O-Acyl Rearrangement to C-19 and C-21 -Substituted Epothilones”, Angew. Chem. Int. Ed., 38(13/14):1971-1974.
Inokuchi et al., 1992, “Opening of Epoxides to Olefins or Halohydrins with Vanadlum(II)-Tetrahydrofuran or Vanadium(III)-Tetrahydrofuran Complexes”, Synlett, No. 6, 510-512.
Kowalski et al., 1997, “Activites of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)” J. Biol, Chem., 272(4):2534-2541.
Kupchan et al., 1971, “Reductive Elimination of Epoxides to Olefins with Zinc-Copper Couple”, J. Org. Chem., 36(9):1187-1190.
Martin et al., 1984, “Epoxides as Alkene Protecting Groups. A Mild and Efficient Deoxygenation”, Tetrahedron Letters, 25(3):251-254.
McMurry et al, 1975, “Reduction of Epoxides to Olefins with Low Valent Titanium”, J. Org. Chem., 40(17):2555-2556.
McMurry et al., 1978, “Some Deoxygenation Reaction with Low-Valent Titanium (TiC3/LiAIH4)”, J. Org. Chem., 43(17):3249-3254.
Meng D., et al., “Remote Effects in Macrolide Formation Through Ring-Forming Olefin Metathesis: An Application to the Synthesis of Fully Active Epothilone Congeners”, J. Am. Chem. Soc., vol. 119, No. 11, 2733-2734 (1997).
Nicolaou K. C., et al., 1996, “An Approach to Epothilones Based on Olefin Metathesis”, Angew. Chem. Int. Ed. Engl., 35(20):2399-2401.
Nicolaou K.C. et al., 1997, “Total Synthesis of Epothilone A: The Macrolactonization Approach”, Angew. Chem. Int. Ed. Engl., 36(5): 525-527.
Nicolaou K.C. et al., 1997, Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, and Cytotoxic Action against Taxoi-Resistant Tumor Cells, Angew. Chem. Int. Ed. Engl., 36(19): 2097-2103.
Nicolaou K.C. et al., 1997, “The Olefin Metathesis Approach to Epothilone A and its Analogues”, J. Am. Chem. Soc., 119(34): 7960-7973.
Nicolaou K.C. et al., 1997, “Total Syntheses of Epothillones A and B via a Macrolactonization-Based Strategy”, J. Am. Chem. Soc., 119(34): 7974-7991.
Nicolaou K.C. et al., 1997, “Synthesis of Epothilones A and B in Solid and Solution Phase”, Nature, 387: 268-272.
Nicolaou K.C. et al., 1997, “Synthesis of Epothilones A and B in Solid and Solution Phase” (Correction to Nature 387, 268-272 (1997), Nature, 390, 100.
Raucher, S., et al., 1986, “Total Synthesis of (+)-Dihydrocostunolide via Tandem Cope-Claisen Rearrangement”, J. Org. Chem., 51(26): 5503-5505.
Sato M. et al., 1982, “Reduction of Organic Compounds with Low-Valent Nioblum (NbCL5/NaAIH4)”, Chem. Letters, 157-160.
Schinzer D. et al., 1997, “Total Synthesis of (−)-Epothilone A”, Angew. Chem. Int. Ed. Engl., 36(5):523-524.
Schobert R., et al., 1990, “Reduction and Isomerization of Oxiranes and—Diazoketones by Various Early Transition Metallocenes”, Synlett, 8: 465-466.
Sharpless K.B., et al., 1972, “Lower Valent Tungsten Halides. A New Class of Reagent for Deoxygenation of Organic Molecules”, J. Amer. Chem. Soc., 94(18): 6538-6540.
Su D.-S. et al., 1997, “Total Synthesis of (−)-Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure-Activity Realationships of the Epothilones
Borzilleri Robert M.
Johnson James A.
Kim Soong-Hoon
Vite Gregory D.
Bristol--Myers Squibb Company
Greenblatt Gary
Kifle Bruck
Winslow Anastasia P.
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