Epothilone compounds and methods for making the same

Details Epothilone compounds and methods for making the same Epothilone compounds and methods for making the same

2006-07-04

2006-07-04

Prats, Francisco C. (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

C435S120000

Reexamination Certificate

active

07070964

ABSTRACT:
The present invention provides bioconversion methods for making epothilone analogs. These analogs differ from the starting material by the addition of one or more hydroxyl groups or by the addition of an epoxide. These compounds, in turn, can be further modified by chemical synthesis.

REFERENCES:
patent: 6583290 (2003-06-01), Julien et al.
patent: 6921650 (2005-07-01), Julien et al.
patent: WO 00/39276 (2000-07-01), None
patent: WO 01/83800 (2001-11-01), None
PCT International Preliminary Examination Report for PCT/US02/36814.

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