Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-02-06
2007-02-06
Powers, Fiona T. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C548S187000, C548S194000, C548S204000
Reexamination Certificate
active
10732698
ABSTRACT:
Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancers agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubulin assembly. The analogs of epothilone are novel. Several of the analogs are demonstrated to have a superior cytotoxic activity as compared to epothilone A or epothilone B as demonstrated by their enhanced ability to induce the polymerization and stabilization of microtubules.
REFERENCES:
patent: 6156905 (2000-12-01), Schinzer et al.
patent: 6242469 (2001-06-01), Danishefsky et al.
patent: 6262904 (2001-07-01), Meynard et al.
patent: 6369234 (2002-04-01), Danishefsky et al.
patent: 6441186 (2002-08-01), Nicolaou et al.
patent: 6531497 (2003-03-01), Nicolaou et al.
patent: 6605599 (2003-08-01), Vite et al.
patent: 6613912 (2003-09-01), Hoefle et al.
patent: 6624310 (2003-09-01), Hoefle et al.
patent: 6656961 (2003-12-01), Danishefsky et al.
patent: 6660758 (2003-12-01), Nicolaou et al.
patent: 6867305 (2005-03-01), Danishefsky et al.
patent: 6921769 (2005-07-01), Danishefsky et al.
patent: 6958401 (2005-10-01), White et al.
patent: 6989450 (2006-01-01), Avery
patent: 7001916 (2006-02-01), Klar et al.
patent: 2003/0134883 (2003-07-01), Myles et al.
patent: 2003/0203938 (2003-10-01), Nicolaou et al.
patent: 2004/0072870 (2004-04-01), Nicolaou et al.
patent: 2005/0033059 (2005-02-01), Danishefsky et al.
patent: 4138042 (1993-05-01), None
patent: WO-93/10121 (1993-05-01), None
Finlay Maurice Raymond Verschoyle
He Yun
King Nigel Paul
Nicolaou Kyriacos C.
Ninkovic Sacha
Lewis Donald G.
Powers Fiona T.
The Scripps Research Institute
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