Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1994-10-07
1999-11-09
Chin, Christopher L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241901, 4353201, 530350, 530825, A61K 3909
Patent
active
059809094
ABSTRACT:
Regions of the PspA protein of the Rx1 strain of Streptococcus pneumoniae have been identified as containing protection-eliciting epitopes which are cross-reactive with PspAs of other S. pneumoniae strains and which is cross-protective. One region comprises the 68-amino acid sequence extending from amino acid residues 192 to 260 of the Rx1 PspA, another region comprises the C-terminal amino acid sequence extending from amino acid residues 293 to 588 of the Rx1 PspA, while a third region comprises the N-terminal amino acid sequence extending from amino acid residues 1 to 115 of the Rx1 PspA.
REFERENCES:
McDaniel et al. Jan. 1991. Infection & Immunity 59(1): 222-228.
Talkington et al. Apr. 1991. Infection & Immunity 59(4): 1285-1289.
McDaniel et al. Abstract No. D-255. Abstracts of the 89.sup.th Annual Meeting of the Amer. Society for Microbiology. New Orleans, La. May 14-18 1989.
Briles David E.
McDaniel Larry S.
Yother Janet L.
Chin Christopher L.
Frommer William S.
Graser Jennifer
Kowalski Thomas J.
UAB Research Foundation
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