Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-01-11
2005-01-11
Housel, James (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S069300, C435S069100, C435S235100, C424S130100, C424S159100, C424S228100
Reexamination Certificate
active
06841353
ABSTRACT:
Antibodies to two new epitopes on the HCV envelope proteins were identified which allow routine detection of native HCV envelope antigens, in tissue or cells derived from the host. The new epitopes are: the E1 region aa 307-326 and the N-terminal hyper variable region of E2 aa 395-415. Surprisingly, we characterised an antibody that reacts with various sequences of the hypervariable domain of E2. Specific monoclonal antibodies directed against these epitopes and allowing routine detection of viral antigen are described.
REFERENCES:
patent: 5308750 (1994-05-01), Mahta
patent: 5514539 (1996-05-01), Bukh
patent: 5610009 (1997-03-01), Watanabe
patent: 5830691 (1998-11-01), Miyamura et al.
patent: 5871962 (1999-02-01), Bukh
patent: 5919454 (1999-07-01), Brechot
patent: 6150134 (2000-11-01), Maertens
patent: 42 09 215 (1993-01-01), None
patent: PCTUS91/08272 (1991-01-01), None
patent: PCTIT92/00081 (1992-01-01), None
patent: PCTUS92/07189 (1992-01-01), None
patent: WO 92 13892 (1992-08-01), None
patent: PCTUS93/00907 (1993-01-01), None
patent: WO 93 18054 (1993-09-01), None
patent: WO 94 05311 (1994-03-01), None
patent: WO9604385 (1996-02-01), None
patent: WO 96 40764 (1996-12-01), None
Ralston et al., “Characterization of Hepatitis C Virus . . . ,” J. Virol 67: 6753-6761 (1993).
Nishihara et al., “Secretion and Purification of Hepatitis C . . . ,” Gene 129; 207-214 (1993).
Choo et al., “Vaccination of Chimpanzees Against . . . Hepatitis C Virus,” ProcNatl Acad Su 91:1294-1298 (1994).
Lanford et al., “Analysis of Hepatitis C Virus . . . ,” Virology 197: 225-235 (1993).
Hiramatsu et al., “Immunohistochemical Detection of Hepatites . . . ,” Hepatology, vol. 16, No. 2, 1992, pp. 306-311, XP002084942 abstract p. 308, left-hand column, line 27-right-hand column, line 13.
Chan et al., “Human Recombinant Antibodies Specific . . . ,” J. General Virology, vol. 77, 1996, pp. 2531-2539, XP002084943 p. 2532, left-hand column, line 32-35 p. 2533, table 1 p. 2537, right-hand column, line 18-27.
Maertens et al., “Mapping of Human and Murine . . . ,” Hepatology, vol. 26, No. 4part2, Oct. 1997, p. 186A XP002084941 A232 the whole document.
Suzuki, T. (1) et al., “Detection of the E1 protein . . . ,” Hepatology, (Oct. 1998) vol. 28, No. 4 part 2, pp. 271A. Meeting Info.: Biennial Scientific Meeting of the International Association for the Study of the Liver and the 49thAnnual Meeting and Postgraduate Courses of the American Association for Th, XP002116634 the whole document.
Buyse Marie-Ange
Depla Erik
Maertens Geert
Chen Stacy B.
Housel James
Innogenetics N.V.
Nixon & Vanderhye P.C.
LandOfFree
Epitopes in viral envelope proteins and specific antibodies... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Epitopes in viral envelope proteins and specific antibodies..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Epitopes in viral envelope proteins and specific antibodies... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3415192