Epitope for prevention of type I diabetes

Details Epitope for prevention of type I diabetes Epitope for prevention of type I diabetes

1995-02-22

1997-01-14

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

530326, A61K 3828, C07K 7700

Patent

active

055941001

ABSTRACT:
The present invention encompasses peptides derived from the 15 residue peptide 9-23, Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly (SEQ ID NO:1), of the B chain of insulin. Peptides of the present invention are capable of acting as tolerogens for preventing type I diabetes.

REFERENCES:
Llarde, A. et al., "Treatment of non-insulin-dependent diabetes mellitus and its complications", Drugs & Aging 4(6):470-491, 1994. See entire article.

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