Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1996-10-04
1999-04-06
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303881, 435326, 435331, 435335, C07K 1624
Patent
active
058920013
ABSTRACT:
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
REFERENCES:
Grabstein et al., "Cloning of a T Cell Growth Factor That Interacs with the .beta. Chain of the Interleukin-2 Receptor," Science 264: 965-968, 1994.
McMahan et al., "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types," EMBO Journal 10(10):2821-2832, 1991.
Lerner et al. (1982) Nature vol. 299, pp. 592-596.
Callard & Gearing (1994) The Cytokine Factsbook, Academic Press Inc., San Diego, CA, pp. 39-40.
Bowie et al. (1990) Science, vol. 247, pp. 1306-1310.
Shimamura et al. (1991), vol. 28, No. 11, Molecular Immunology, pp. 1155-1161.
Anderson Dirk M.
Eisenman June R.
Fung Victor
Grabstein Kenneth H.
Rauch Charles
Immunex Corporation
Mertz Prema
Ulm John
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