Epitheliocyte growth accelerator

Details Epitheliocyte growth accelerator Epitheliocyte growth accelerator

1991-12-27

1994-08-30

Hill, Jr., Robert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530399, 4352401, C07K 1300, A61K 3702, A61K 3766

Patent

active

053428315

ABSTRACT:
An epitheliocyte growth accelerator containing a hepatocyte growth factor (HGF) as the active ingredient. In the present invention, the HGF maybe derived from human tissues, animal tissues, or blood components, or it may be produced genetic engineering. In this regard, the host cell to be used in the genetic engineering may be selected from among Escherichia coli, Bacillus subtilis, yeasts, filamentous fungi, plant cells and animal cells. The epitheliocyte growth accelerator of the present invention specifically accelerates growth of normal epitheliocytes, and improves cell motility.
The epitheliocyte growth accelerate of the present invention does not have fibroblast growing activity or canceration accelerating activity.

REFERENCES:
patent: 5004805 (1991-04-01), Gohda et al.
Nakamura et al. "Molecular Cloning and Expression of Human Hepatocyte Growth Factor" Nature 342 440-443, Nov. 23, 1989.
Rubin et al. "A broad-spectrum human lung fibroblast-derived mitogen . . . " Proc. Natl. Acad. Sci. USA 88 415-419 Jan. '91.
Gherardi et al., "Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement," Proc. Natl. Acad. Sci. USA, 86, 5844-5848 (1989).
Kan et al., "Hepatocyte Growth Factor/Hepatopoietin A Stimulates the Growth of Rate Kidney Proximal Tubule Epithelial Cells (RPTE), Rat Nonparenchymal Liver Cells, Human Melanoma Cells, Mouse Keratinocytes and Stimulates Anchorage-Independent Growth of SV-40 Transformed RPTE," Biochem. and Biophys. Res. Comm., 174(1), 331-337 (1991).
Zarnegar et al., "NH.sub.2 -Terminal Amino Acid Sequence of Rabbit Hepatopoietin A, A Heparin-Binding Polypeptide Growth Factor for Hepatocytes," Biochem. and Biophys. Res. Comm., 163(3), 1370-1376 (1989).

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